Cardiovascular Inflammation Reduction Trial (CIRT): A randomized double-blind placebo controlled event-driven trial of weekly low-dose methotrexate (LDM) in the prevention of recurrent cardiovascular events among stable post-myocardial infarction patients with type 2 diabetes or metabolic syndrome
This is an event-driven, multi-center, randomized, double-blind, placebo-controlled trial to determine whether methotrexate reduces heart attacks, strokes, or death in people who have already had at least one heart attack and have type 2 diabetes or metabolic syndrome. Metabolic syndrome is defined as a combination of problems including a large ...
Determination of B-cell responsiveness to the incretin hormones GLP-1 and GIP in Cystic Fibrosis (PRIME)
The mechanisms underlying cystic fibrosis related diabetes (CFRD) pathophysiology must be better defined if care for people with CFRD is to be optimized or if development of CFRD is to be interrupted. Detailed studies of insulin secretion in CF are required to achieve this goal since 1) subtle insulin secretion ...
Effect of Hybrid Closed-Loop Insulin Delivery on Glucose Counterregulation in Long Standing Type 1 Diabetes: A Proof of Concept, Mechanistic, Single-Arm Clinical Trial
Can a type 1 diabetic adult avoid low glucoses & regain hypoglycemia awareness using a hybrid closed loop insulin delivery system? Involvement is 22 months (13 visits) & includes a4-week Screening Phase & an 18-month Intervention Phase. 3 Hyperinsulinemic Clamps done at: Baseline (before starting to use the device & ...
Glucagon-Like Peptide-1 (GLP-1) Metabolism in the Setting of Acute Neprilysin Inhibition
The purpose of this study is to determine if the medicine sacubitril/ valsartan will raise levels of the hormone glucagon-like peptide-1 (GLP-1) after a meal that may be beneficial for controlling blood sugar. We are also measuring if this pill will lower triglycerides. A large percent of people with high ...
Predictors of response to IMPaCT intervention
The IMPaCT community health worker intervention is effective at improving cardiovascular risk factors and is being disseminated more widely. Although overall effective, over 30% of patients did not improve control of their selected cardiovascular risk factor despite a 6 month dose of IMPaCT. One key question is: Are there characteristics ...
Barriers to and facilitators of health for incarcerated individuals with cardiovascular disease risk factors transitioning to the community
When incarcerated individuals are released to the community, they face substantial challenges related to securing housing, employment, social support, and health care. As a result, former inmates face a risk of death 3.5 times that of the general population. Cardiovascular disease affects 22% of inmates and is the second leading ...
Vascular Inflammation in Psoriasis- Apremilast Trial (VIP-A Trial)
Psoriasis is a systemic (affecting the entire body) inflammatory (causing redness, swelling, and pain) disorder and not just a disorder of the skin. Evidence has shown that psoriasis is a risk factor for developing high blood pressure, diabetes, obesity, high cholesterol, heart attack, and stroke. The purpose of this study ...
Effectiveness of sitagliptin in Cystic Fibrosis with impaired glucose tolerance
Patients with Cystic Fibrosis often suffer from glucose intolerance. This study will evaluate how effective sitagliptin, a DPP-IV inhibitor, is at improving glycemic control in the Cystic Fibrosis population. Participants will complete baseline testing, then will be asked to take a once-daily pill for 6-months before completing follow-up testing. Participants ...
Normal Donor Human Bone Marrow Donation for Research
We are looking for healthy volunteers to donate bone marrow for research purposes. The Stem Cell & Xenograft Core provides bone marrow to laboratories on Penn’s campus researching leukemia and other blood disorders
Mechanisms of Increased Cardiovascular Disease Risk in Women with Migraine
Healthy volunteers are needed for an observational research study at HUP and CHOP. This study examines the relationship between migraine headaches, nutrition, inflammation, and cardiovascular disease risk in women. The study involves a telephone screening and one in-person visit that will last 6-8 hours. During this visit participants will undergo ...