Determination of B-cell responsiveness to the incretin hormones GLP-1 and GIP in Cystic Fibrosis (PRIME)
The mechanisms underlying cystic fibrosis related diabetes (CFRD) pathophysiology must be better defined if care for people with CFRD is to be optimized or if development of CFRD is to be interrupted. Detailed studies of insulin secretion in CF are required to achieve this goal since 1) subtle insulin secretion ...
Effect of Hybrid Closed-Loop Insulin Delivery on Glucose Counterregulation in Long Standing Type 1 Diabetes: A Proof of Concept, Mechanistic, Single-Arm Clinical Trial
Can a type 1 diabetic adult avoid low glucoses & regain hypoglycemia awareness using a hybrid closed loop insulin delivery system? Involvement is 22 months (13 visits) & includes a4-week Screening Phase & an 18-month Intervention Phase. 3 Hyperinsulinemic Clamps done at: Baseline (before starting to use the device & ...
Barriers to and facilitators of health for incarcerated individuals with cardiovascular disease risk factors transitioning to the community
When incarcerated individuals are released to the community, they face substantial challenges related to securing housing, employment, social support, and health care. As a result, former inmates face a risk of death 3.5 times that of the general population. Cardiovascular disease affects 22% of inmates and is the second leading ...
Glucagon-Like Peptide-1 (GLP-1) Metabolism in the Setting of Acute Neprilysin Inhibition
The purpose of this study is to determine if the medicine sacubitril/ valsartan will raise levels of the hormone glucagon-like peptide-1 (GLP-1) after a meal that may be beneficial for controlling blood sugar. We are also measuring if this pill will lower triglycerides. A large percent of people with high ...
Cardiovascular Inflammation Reduction Trial (CIRT): A randomized double-blind placebo controlled event-driven trial of weekly low-dose methotrexate (LDM) in the prevention of recurrent cardiovascular events among stable post-myocardial infarction patients with type 2 diabetes or metabolic syndrome
This is an event-driven, multi-center, randomized, double-blind, placebo-controlled trial to determine whether methotrexate reduces heart attacks, strokes, or death in people who have already had at least one heart attack and have type 2 diabetes or metabolic syndrome. Metabolic syndrome is defined as a combination of problems including a large ...
Vascular Inflammation in Psoriasis- Apremilast Trial (VIP-A Trial)
Psoriasis is a systemic (affecting the entire body) inflammatory (causing redness, swelling, and pain) disorder and not just a disorder of the skin. Evidence has shown that psoriasis is a risk factor for developing high blood pressure, diabetes, obesity, high cholesterol, heart attack, and stroke. The purpose of this study ...
Normal Donor Human Bone Marrow Donation for Research
We are looking for healthy volunteers to donate bone marrow for research purposes. The Stem Cell & Xenograft Core provides bone marrow to laboratories on Penn’s campus researching leukemia and other blood disorders
Research Study for women with PCOS (Polycystic ovary syndrome)
Healthy women ages 18-45 with Polycystic Ovary Syndrome (PCOS) are invited to screen for a study participation in an investigational drug study
Randomized Controlled Trial Examining the Effects of Meal Timing Among Obese Individuals
The timing of food consumption is now recognized as a significant contributor to body weight regulation and metabolic functioning. However, most studies have been in rodents or normal weight persons. The proposed study extends this work, including Drs. Allison and Goel's previous work on the randomized study of daytime vs. ...