Clinical Research Opportunities

Penn Medicine is conducting studies to develop new ways to prevent, diagnose, and treat disease. You might be eligible to participate

Penn Medicine is conducting studies to develop new ways to prevent, diagnose, and treat disease. You might be eligible to participate

Penn Medicine is conducting medical studies to develop new diagnostic and clinical treatments to improve current standards of care.

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Recently Added/Updated trials

Chronic Hypertension and Pregnancy (CHAP) Trial Maternal Follow-up Study

Female
This is a long-term follow up of participants enrolled in the CHAP trial during a 5-year window starting between 0-6 years until 5-10 years after their participation in the original CHAP trial. The goal is to determine whether treatment of mild CHTN in pregnancy influences maternal risk of cardiovascular disease (CVD) and to evaluate the long-term effect of superimposed preeclampsia on CVD outcomes in women who had CHTN.

Understanding the long-term impact of COVID on children and families

All genders
Observational
A Multi-Center Observational Study: The RECOVER Post Acute Sequelae of SARS-CoV-2 (PASC) Pediatric Cohort Study. This is a combined retrospective and prospective, longitudinal, observational meta-cohort of individuals age 0-25 years who will enter the cohort with and without SARS-CoV-2 infection at varying stages before and after infection. Individuals with and without SARS-CoV-2 infection and with or without PASC symptoms will be followed to identify risk factors and occurrence of PASC. This study will be conducted in the United States and participants will be recruited through inpatient, outpatient, and community-based settings. Study data including age, demographics, social determinants of health, medical history, vaccination history, details of acute SARS-CoV-2 infection, overall health and physical function, and PASC symptoms will be reported by participants or collected from the electronic health record using a case report form at specified intervals. Biologic specimens will be collected at specified intervals, with some tests performed in local clinical laboratories and others performed by centralized research centers or banked in the Biospecimen Repository. Advanced clinical examinations and radiologic examinations will be performed at local study sites with cross-site standardization. 
 Environmental influences on Child Health Outcomes

Environmental influences on Child Health Outcomes

Female
ECHO stands for Environmental influences on Child Health Outcomes. ECHO is a large research program supported by the National Institutes of Health that aims to improve the health of children and teens in the United States. ECHO will enroll more than 50,000 women, men, babies, children, and teens to partner with researchers so we can learn how things in our lives (our environment) affect how healthy our children and teens are. When we know this, we can make choices to improve health.
 Continuation of the nuMoM2b Heart Health Study

Continuation of the nuMoM2b Heart Health Study

18-99 years
Female
Interventional
The nuMoM2b Heart Health Study (nuMoM2b-HHS) has followed a demographically diverse cohort of women enrolled and richly phenotyped during their first pregnancy, with data and biospecimens prospectively collected for up to 7 years thereafter. The overarching scientific goal of this study is to define the relationship between adverse pregnancy outcomes (APOs) and CVD to optimize CVD prediction, prevention, and treatment strategies for women. Continued follow-up of this observational cohort, building on a foundation of existing high-quality data, biospecimens, and administrative structures with a robust framework for ancillary study development and implementation, provides a unique opportunity to address knowledge gaps regarding the early mechanisms and trajectory of CVD in women.

NRG-GI008: Colon Adjuvant Chemotherapy Based on Evaluation or Residual Disease (Circulate-North America)

All genders
Phase 2/3
This Phase II/III trial will evaluate the what kind of chemotherapy to recommend to patients based on the presence or absence of circulating tumor DNA (ctDNA) after surgery for colon cancer.This study is Enrolling by Invitation only at Lancaster General Health - ABBCI.

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Participate in medical studies to develop new diagnostic and clinical treatments and improve current standards of care.

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Currently seeking healthy volunteers for research studies.

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CureTalks@Penn interviews Penn Medicine physicians about their cutting edge research and clinical trials. Our goal is to inform patients, care-givers, patient advocates and other physicians about research that occurs at Penn Medicine.

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