Penn Medicine is conducting medical studies to develop new diagnostic and clinical treatments to improve current standards of care.
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Recently Added/Updated Trials
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Testing Novel Pharmacogenetic and Adherence Optimization Treatments to Improve the Effectiveness of Smoking Cessation Treatments for Smokers with HIV
We will randomize 488 smokers (self-reported daily smoking for 30 days) with a confirmed HIV diagnosis (by medical chart) to receive 12 weeks of: 1 ... Read more
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Investigating Potential of Personalized Biomarkers in Redefining Treatment Response in Patients with Glioblastoma using Multiparametric MRI and Liquid Biopsy
This study aims to investigate 30 patients with a diagnosis of Glioblastoma to develop a decision support system by incorporating advanced MR imaging, liquid biopsy ... Read more
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A Phase II Study of the Anti-GITR Agonist INCAGN01876 and the PD-1 Inhibitor INCMGA00012 in Combination with Stereotactic Radiosurgery in Recurrent Glioblastoma
The following protocol is a phase II study of the combination of the GITR agonist monoclonal antibody INCAGN01876, the anti-PD1 monoclonal antibody INCMGA00012, and SRS ... Read more
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Comparison of the Short-Term Effect of Dietary Carbohydrate Restriction Versus Exogenous Ketone Supplementation on Myocardial Glucose Suppression and Timing to Achieve a State of Ketosis Using FDG PET/CT Serial Imaging
Randomized, single blinded crossover trial testing optimal interventions to adequately suppress myocardial glucose suppression. We will enroll up to 50 subjects in order to reach ... Read more
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Pilot Study of EsoCheck Compared to Biopsies and Brush Cytology During Endoscopy for Evaluation of Eosinophilic Esophagitis
Eosinophilic esophagitis (EoE) is a chronic inflammatory condition of the esophagus that can lead to remodeling and stricture formation. To assess response to therapy, upper ... Read more
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A Randomized Double-Blind Placebo Controlled Trial of Abatacept (CTLA4-Ig) in Giant Cell Arteritis
Please reference protocol section 2. Read more
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Does vaginal delivery of combined hormonal contraception affect the risk of metabolic syndrome in overweight/obese women with PCOS?
Please see attached protocol under Section 1, titled "Background and Study Rationale". Read more
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Pharmacogenetic Study of the medication Ondansetron in Alcohol Use Disorder
The primary study objective is to determine the efficacy of ondansetron (0.33 mg twice daily) administered orally for a period of 16 weeks in ... Read more
