An Evaluation of Maintenance Therapy Combination Mirvetuximab Soravtansine and Olaparib (UPROAR)

Brief description of study

This study aims to learn more about the use of Mirvetuximab soravtansine and Olaparib as a
maintenance therapy after completion of prior therapy for recurrent platinum sensitive ovarian,
peritoneal and fallopian tube cancer. Mirvetuximab soravtansine is an effective antibody drug
conjugate that targets folate receptor alpha. Olaparib is one of three drugs currently approved
by the U.S. Food and Drug Administration (FDA) in the setting of ovarian cancer.

Detailed description of study

If you join the study, you will receive a combination therapy of Mirvetuximab soravtansine and

Olaparib. Study treatment will be conducted until disease progression or other reason for discontinuation.

Cycles will be 21 days. You will be administered Mirvetuximab soravtansine on Day 1 and take

the study drug Olaparib on Day 1 through Day 21. You will continue to repeat this dosing

schedule until your study doctor tells you otherwise. At the beginning of each cycle, we will have

you come into clinic for the following procedures/assessments:

- We will ask you about medications you are taking, adverse events you are experiencing,

past medical procedures, and any ocular symptoms you are experiencing

- Serum pregnancy for women of childbearing potential/not underwent surgical

menopause.

- We will ask you about your Olaparib medication and dispense you a new cycle of

medication. The doctor may adjust your dose if necessary.

- We will administer you your Mirvetuximab soravtansine. The doctor may adjust your

dose if necessary.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

Conditions:
recurrent platinum sensitive ovarian, peritoneal and fallopian tube cancer
Age: 18 Years
Gender: Female

Inclusion Criteria:

Provision to sign and date the consent form
Stated willingness to comply with all study procedures and be available for the duration of the study
Be a woman aged ≥18 years of age
Patients must have an Eastern Cooperative Oncology Group Performance Status (ECOG PS) of 0 or 1
Patients must have a confirmed diagnosis of high-grade serous or endometrioid EOC, primary peritoneal cancer, or fallopian tube cancer
Patients must have platinum-sensitive disease defined as radiographic progression greater than 6 months from last dose of most recent platinum therapy
Patients must have had documented complete or partial response, or stable disease, as defined by RECIST 1.1, from last line of platinum therapy
Patients must have available archival tissue block or slides to confirm FRalpha positivity
Patients' tumor must have FRalpha high or medium expression
Prior anticancer therapy:
- Patients must have received at least one prior platinum-based chemotherapy regimen for platinum sensitive recurrent disease.
- Most recent prior chemotherapy regimen must have consisted of at least 4 completed cycles and no more than 8 completed cycles
- Most recent prior chemotherapy regimen must have been platinum based
- Patients must have had testing for BRCA mutation (tumor or germline) and, if positive, must have received a prior PARP inhibitor as either treatment or maintenance therapy
- Neoadjuvant +/- adjuvant therapies are considered 1 line of therapy
- Maintenance therapy (eg, Bevacizumab, PARP inhibitors) will be considered part of preceding line of therapy (ie, not counted independently)
- Therapy changed due to toxicity in the absence of progression will be considered part of the same line (ie, not counted independently)
- Hormonal therapy will be counted as a separate line of therapy unless it was given as maintenance
Patients must have adequate hematologic, liver, and kidney function as defined as:
- Absolute neutrophil count (ANC) ≥ 1.5 x 109/L (1500/µL)
- Platelet count ≥ 100 x 109/L (100,000 µL)
- Hemoglobin ≥ 10.0 g/dL with no blood transfusion in the past 28 days
- Serum creatinine ≤ 1.5 x upper limit of normal (ULN)
- Patients must have creatinine clearance estimated of ≥51 mL/min using the Cockcroft-Gault equation or based on a 24 hour urine test
- Aspartate aminotransferase (AST)(Serum Glutamic Oxaloacetic Transaminase (SGOT)) and alanine aminotransferase (ALT) (Serum Glutamic Pyruvate Transaminase (SGPT)) ≤ 2.5 x ULN unless liver metastases are present in which case they must be ≤ 5x ULN
- Serum bilirubin ≤ 1.5 x ULN (patients with documented diagnosis of Gilbert syndrome are eligible if total bilirubin < 3.0 x ULN)
- Serum albumin ≥ 2 g/dL

Exclusion Criteria:

Patients with clear cell, mucinous, sarcomatous, low grade/borderline, germ cell, or sex-cord stromal type ovarian tumor
Patients who have progressed through most recent chemotherapy regimen. Stable disease (SD) is permissible.
Patients receiving any systemic chemotherapy or radiotherapy (except for palliative reasons) within 3 weeks prior to study treatment
Patients with active or chronic corneal disorders, history of corneal transplantation, or active ocular conditions require ongoing treatment/monitoring, such as uncontrolled glaucoma, wet age-related macular degeneration requiring intravitreal injections, active diabetic retinopathy with macular edema, macular degeneration, presence of papilledema, and/or monocular vision
Patients with myelodysplastic syndrome/acute myeloid leukemia or with features suggestive of MDS/AML.
Patients considered a poor medical risk due to a serious, uncontrolled medical disorder, non-malignant systemic disease or active, uncontrolled infection. Examples include, but are not limited to:
- Uncontrolled major seizure disorder
- Unstable spinal cord compression
- Any psychiatric disorder that prohibits obtaining informed consent.
- Active hepatitis B or C infection (whether or not on active antiviral therapy)
- Immunocompromised patients, e.g., patient who are known to be serologically positive for human immunodeficient virus(HIV)
- Active cytomegalovirus infection
- Any other concurrent infectious disease requiring IV antibiotics within 2 weeks prior to the first dose of MIRV
Patients with a history of multiple sclerosis (MS) or other demyelinating disease and/or Lambert-Eaton syndrome (paraneoplastic syndrome)
Patients with clinically significant cardiac disease including, but not limited to, any of the following
- Myocardial infarction ≤ 6 months prior to first dose
- Uncontrolled ventricular arrhythmia, recent (within 3 months)
- Superior vena cava syndrome
- Unstable angina pectoris
- Uncontrolled congestive heart failure (New York Heart Association > class II)
- Uncontrolled ≥ Grade 3 hypertension (per CTCAE)
- Uncontrolled cardiac arrhythmias
Patients with a history of hemorrhagic or ischemic stroke within 6 months prior to enrollment
Patients with a history of cirrhotic liver disease (Child-Pugh Class B or C)
Patients with a previous clinical diagnosis of noninfectious interstitial lung disease (ILD) or Extensive interstitial bilateral lung disease on High Resolution Computed Tomography (HRCT) scan , including noninfectious pneumonitis
Persistent toxicities (>Common Terminology Criteria for Adverse Event (CTCAE) grade 2) caused by previous cancer therapy, excluding alopecia
Patients requiring use of folate-containing supplements (eg, folate deficiency)
Concomitant use of known strong CYP3A inhibitors (eg. itraconazole, telithromycin, clarithromycin, protease inhibitors boosted with ritonavir or cobicistat, indinavir, saquinavir, nelfinavir, boceprevir, telaprevir) or moderate CYP3A inhibitors (eg. ciprofloxacin, erythromycin, diltiazem, fluconazole, verapamil). The required washout period prior to starting study treatment is 2 weeks.
Concomitant use of known strong (eg. phenobarbital, enzalutamide, phenytoin, rifampicin, rifabutin, rifapentine, carbamazepine, nevirapine and St John's Wort ) or moderate CYP3A inducers (eg. bosentan, efavirenz, modafinil). The required washout period prior to starting study treatment is 5 weeks for enzalutamide or phenobarbital and 3 weeks for other agents.
Patients with prior hypersensitivity to monoclonal antibodies (mAb)
Previous allogenic bone marrow transplant or double umbilical cord blood transplantation (dUCBT).
Women who are pregnant or breastfeeding, and who do not agree to use a highly effective contraceptive method(s) while on study drug and for at least 3 months after the last dose of MIRV. Females of childbearing potential must have a negative serum pregnancy test within 72 hours of study entry. Refer to section 6.9.6 for details.
Patients who received prior treatment with MIRV or other FRα- targeting agents
Patients with duodenal stent or other GI disorder/defect that would interfere with absorption of oral medication
- Includes patients unable to swallow orally administered medication and patients with gastrointestinal disorders likely to interfere with absorption of the study medication
Patients with known untreated or symptomatic central nervous system (CNS) metastases
Patients with a history of other malignancy within 3 years prior to enrollment
- Note: patients with tumors with a negligible risk for metastasis or death (eg, adequately controlled basal-cell carcinoma or squamous-cell carcinoma of the skin, or carcinoma in situ of the cervix or breast) are eligible
Prior known hypersensitivity reaction to study drugs and/or any of their excipients
Minor or major surgical procedure within 2 weeks of starting study treatment and patients must have recovered from any effects of any major surgery.
Inability to comply with study and follow-up procedures
Patients deemed otherwise clinically unfit for clinical trial per investigators discretion.

Updated on 11 Apr 2024. Study ID: 854860

You have contacted , on

Your message has been sent to the study team at ,

A copy of the message has been sent to your email

What happens next?

You can expect the study team to contact you via email or phone in the next few days.
Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

By sending a message, I agree that my data will be sent to a representative for the selected site and processed in accordance with this website's Privacy Policy (see link in footer).