Mapping Muscle Specific Metabolism in Different Age Groups
Brief description of study
The purpose of the study is to determine the changes in muscle metabolites by MRI before and after exercise. The MRI will be performed while performing mild exercise of the calf muscle for 1-3 minutes. We are actively recruiting adults between 18-30, 45-55 and 70-80. Volunteers will be non-diabetic, have a BMI of 30 or below, and not taking a statin for their cholesterol.
Detailed description of study
The visit to the research center at Penn will occur initially, followed by the MRI scan. Blood will be drawn and sent to the lab to measure blood glucose, metabolic profile, lipid panel and other key markers. Height, weight, waist-to-hip ratio, age, medications/supplements taken, and chronic health conditions will be recorded. A survey on physical activity will be administered. An actigraph, or activity monitor will be assigned to wear for at least 7 days, if willing.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
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Conditions:
Healthy
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Age: Between 18 Years - 80 Years
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Gender: All
Inclusion
- Adult healthy volunteer
- Age in years: 18-35; 45-55; or 70-80
- Willing to undergo all study procedures.
Exclusion
- Chronic disease as determined by investigators
- Diabetes
- Use of statin drug or any other drug known or suspected of impacting muscle bioenergetics.
- Any contraindication identified for MRI scan including pregnancy
Updated on
10 Apr 2024.
Study ID: 853946
Pre-Screener
