UPCC 42422: A Phase 1/2 Multicenter Open-Label Randomized Dose Ranging and Expansion Study of the Combination of Gilteritinib Venetoclax and Azacitidine in Patients with Newly Diagnosed FLT3 Mutated Acute Myeloid Leukemia (AML) not Eligible for Intensive Induction Chemotherapy

Brief description of study

Gilteritinib, given with venetoclax and azacitidine, is a potential new treatment for people with acute myeloid leukemia with changed FLT3 gene where chemo is not an option due to old age/other conditions. Aims of this study: find suitable doses of gilteritinib, venetoclax and azacitidine as combined treatment; to learn how they are processed by/act upon the body; remission rate; check for medical problems during treatment. We would like to rely on Advarra as the IRB of record for this study.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

Conditions:
Medical Research
Age: - 99 Years
Gender: All

Updated on 14 Jun 2023. Study ID: 852832

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