Neurosensory Abnormalities in SymptomAtic Ocular Surface Patients

Primary Objectives: 1. To establish the prevalence of neuropathic corneal pain in patients with ocular surface discomfort. 2. To assess the overlap of neuropathic corneal pain with dry eye disease in patients in diseases that are currently thought to be mutually exclusive. 3. To establish the prevalence of subtypes of patients with neuropathic corneal pain or with a neuropathic component of dry eye in patients with ocular surface discomfort. Secondary Objective(s): 1. To assess the overlap of neuropathic corneal pain and contact lens discomfort. 2. To assess for differences in in vivo confocal microscopy measures between dry eye disease patients and neuropathic corneal pain patients as well as the subtypes of neuropathic corneal pain. Percent of subjects who report increased ocular surface discomfort upon challenge with hyperosmolar saline. Percent of subjects who report ocular surface discomfort, and either do or do not exhibit signs of dry eye disease as defined by TBUT, Schirmers test, and staining, and have an increase in VAS score of more than 2 steps upon instillation of hypertonic saline. Percent of subjects who report ocular surface discomfort, and have a decrease, partial decrease, or no change in VAS score upon instillation of proparacaine. Percent of contact lens wearers who report discomfort when wearing their contact lenses, and either do or do not exhibit signs of dry eye disease as defined by TBUT, Schirmers test, and staining, and have an increase in VAS score of more than 2 steps upon instillation of hypertonic saline. The following in vivo confocal microscopy parameters -Dendritic cell density -Nerve fiber density -Microneuroma density

You may be eligible for this study if you meet the following criteria:

• Conditions:
  Medical Research
• Age: - 99 Years
• Gender: All