Hair Probe to Enhance Cerebral Optical Monitoring of Stroke

A novel device, developed at the University of Pennsylvania, utilizes diffuse correlation spectroscopy (DCS), which allows for real-time, continuous bedside monitoring of CBF using near infrared light. This non-invasive device holds great promise for monitoring cerebral hemodynamics in stroke patients. Prior work from our group has used this device to quantify changes in CBF in stroke patients during postural change, intravenous fluid administration, and breathing exercises. We are currently using this instrument to monitor cerebral hemodynamics in during mechanical thrombectomy for stroke due to large vessel occlusion. Currently, the optical probe can reliably measure over the forehead region. However, hair causes light diffusion and hence limits the ability to quantify CBF through hair covered surfaces. In the case of a stroke, it is critical that specific brain regions be monitored. For example, if the stroke is affecting the back of the brain, measuring over the forehead might not provide useful information. Our group has developed a new hair probe, which uses small cylinders prevent hair from occluding the light source or detectors. This permits more light to reach the scalp, and in turn, the brain. Here we propose da study using this probe to measure baseline CBF values in stroke patients, comparing the forehead region with the region of the stroke, as confirmed on neuroimaging. We hypothesize that this probe will mitigate the previous effects of hair on the DCS probe. By comparing the readings of CBF from the specialized hair probe placed on the forehead to the hair, this study will provide additional insight to human cerebral hemodynamics, and support diffuse correlation spectroscopy as a means of measuring CBF in more areas of the brain. This study will support the effectiveness and versatility of this bedside CBF monitor.

You may be eligible for this study if you meet the following criteria:

• Conditions:
  stroke
• Age: - 99 Years
• Gender: All