Preoperative use of radiation boost to enhance effectiveness of immune checkpoint blockade therapy in operable breast cancer

Brief description of study

Our study is a Phase 1Ib/2 clinical trial to evaluate the safety and feasibility of the combination of radiotherapy (RT) in a single fraction of 7 Gy with pembrolizumab in patients with operable breast cancer. We will employ a Simon Two Stage design to evaluate the safety, feasibility, and efficacy of combination radiation boost and a single pembrolizumab infusion prior to definitive surgery.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

Conditions:
breast cancer
Age: - 99 Years
Gender: All

Updated on 09 Mar 2024. Study ID: 833464

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