Optimizing Neuromodulation through Individualized Stimulation Frequencies

Brief description of study

Transcranial magnetic stimulation (TMS) is a non-invasive mechanism for stimulating brain regions in humans. TMS can potentiate or inhibit activity in various brain regions, and it allows researchers to exert causal control to explore and define network connectivity among brain regions. Using real-time brain readouts combined with interleaved TMS/fMRI, we will compare across subjects the optimal and the least optimal stimulation frequency based on individualized functional connectivity networks. By comparing brain and behavioral changes after three days of neuromodulation at either optimal or least optimal stimulation frequency, we aim to explore whether optimal stimulation frequency will lead to more robust brain and behavior responses to repetitive TMS (rTMS).

Detailed description of study

Eligibility Criteria:

- 18-60 years old

- Right-handed

- No history of any mental illness

- Able to have an MRI and receive TMS

Participation Includes:

- Visit 1 (Remote): Initial Screening Visit and Clinical Interview (1-3 hours)

- Visit 2 (In-Person): Baseline MRI Scan (~2 hours)

- Visit 3 (In-Person): MRI Scan with TMS (~2 hours)

- Visit 4 - 6 (In-Person): TMS Sessions #1 (~1 hour each)

- Visit 7 (In-Person): MRI Scan with TMS (~1.5 hours)

- Visit 8 - 10 (In-Person): TMS Sessions #2 (~1 hour each)

- Visit 11 (In-Person): MRI Scan with TMS (~1.5 hours)

- Monetary Compensation

If you are interested in participating, please complete our online screening form at this link and select "Individualized Loop TMS": https://is.gd/cndslab

Eligibility of study

You may be eligible for this study if you meet the following criteria:

Conditions:
Healthy Volunteer
Age: Between 18 Years - 60 Years
Gender: All

Updated on 09 Mar 2024. Study ID: 832891

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