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Found 139 trials trials

A listing of trials medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

 The POLAR Trial - Positive End-Expiratory Pressure (PEEP) Levels during Resuscitation of Preterm Infants at Birth

The POLAR Trial - Positive End-Expiratory Pressure (PEEP) Levels during Resuscitation of Preterm Infants at Birth

All genders
Phase 3
Interventional
The POLAR Trial - Positive End-Expiratory Pressure (PEEP) Levels during Resuscitation of Preterm Infants  at Birth
 Direct Lysis of Staph Aureus Resistant Pathogen Trial of Exebacase (DISRUPT)

Direct Lysis of Staph Aureus Resistant Pathogen Trial of Exebacase (DISRUPT)

12-99 years
All genders
Phase 3
Interventional
The purpose of this superiority study is to evaluate the efficacy and safety of exebacase in addition to standard of care antibiotics (SoCA) compared with SoCA alone for the treatment of patients with Staphylococcus aureus (S. aureus) bloodstream infections (BSI), including right-sided infective endocarditis (IE). Patients will be randomized to …
 The Gen-Y Study: Randomized trial of universal vs. guideline-directed germline testing among young adults with cancer

The Gen-Y Study: Randomized trial of universal vs. guideline-directed germline testing among young adults with cancer

18-40 years
All genders
Our study aims to determine whether genetic testing should be recommended for young adults with cancer. This type of testing can show if your cancer may be caused by inherited risk.  This information can help guide effective screening and treatment for cancer in young adults and their families. This is …
 Cervical Ripening as an Outpatient Method Using the Foley: A Randomized Trial (COMFORT)

Cervical Ripening as an Outpatient Method Using the Foley: A Randomized Trial (COMFORT)

18-55 years
Female
Induction of labor normally starts in the hospital. The purpose of this research study is to look at starting your induction at home and see if it lowers your chances of having a c-section compared to starting your induction in the hospital. First time moms are being asked to volunteer …
 LCAT Deficiency Disorders: natural history and identification of biomarkers

LCAT Deficiency Disorders: natural history and identification of biomarkers

1-99 years
All genders
Familial lecithin:cholesterol acyl transferase (LCAT) deficiency (FLD) is a rare, hereditary disease with no treatment. It is caused by mutations in the gene for LCAT, an enzyme that is made in the liver and plays a role in the body’s ability to process (“metabolize”) cholesterol. People with FLD have very …
 Investigational COVID-19 Vaccine Trial

Investigational COVID-19 Vaccine Trial

18-60 years
All genders
Phase 1
This clinical research trial is being conducted to find out whether the administration of two investigational dMab products (not approved by the US FDA) with an investigational device is safe, tolerated, and can produce enough antibodies in your blood that may indicate the ability to prevent infection of COVID-19.
 Antiviral medication to reduce symptoms of COVID-19: A phase 3, placebo-controlled trial

Antiviral medication to reduce symptoms of COVID-19: A phase 3, placebo-controlled trial

18-64 years
All genders
Phase 3
If you tested positive for COVID-19 within the last 5 days, you may be eligible to participate in a research study to test the ability of a pill to reduce COVID-19 symptoms.

Healey ALS Platform Trial - Regimen F ABBV-CLS-7262

18-100 years
All genders
Phase 2
ABBV-CLS-7262 is a prodrug that is converted in vivo to the pharmacologically active parent compound A-1684909. A-1684909 is a central nervous system (CNS)-penetrant, eukaryotic translation initiation factor 2B (eIF2B) activator that attenuates the integrated stress response (ISR), a highly conserved cellular mechanism hypothesized to be important in the pathophysiology of …
 A Study to Evaluate Efficacy and Safety of Treatment With Lecanemab in Participants With Preclinical Alzheimer's Disease and Elevated Amyloid and Also in Participants With Early Preclinical Alzheimer's Disease and Intermediate Amyloid

A Study to Evaluate Efficacy and Safety of Treatment With Lecanemab in Participants With Preclinical Alzheimer's Disease and Elevated Amyloid and Also in Participants With Early Preclinical Alzheimer's Disease and Intermediate Amyloid

55-80 years
All genders
Phase 3
The Study is two research trials aimed at preventing Alzheimer’s disease (AD) dementia. One is called AHEAD-3 and the other is called AHEAD-45. AHEAD-3 studies people with intermediate amyloid, while AHEAD-45 studies people with elevated amyloid. Research studies are designed to gain scientific knowledge that may help people in the …

Penn Uterine Transplantation for Uterine Factor Infertility (UNTIL) Trial

21-40 years
Female
The UNTIL Trial is a new clinical research trial that offers uterine transplantation to women with uterine factor infertility (UFI). Participation in this trial requires going through an extensive selection process, creation of embryos through in vitro fertilization, and multiple surgeries. Study participants may remain in the study for 5-10 …
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