FIX-HF-5CA: Continued Access Protocol for the Evaluation of the OPTIMIZER Smart System in Subjects with Moderate-to-Severe Heart Failure with Ejection Fraction between 25% and 45%
Two previous protocols (FIX-HF-5 and FIX-HF-5C) under IDE G0300099 have been conducted to evaluate the safety and efficacy of the Optimizer System with CCM (cardiac contractility modulation) therapy. The FIX-HF-5CA protocol allows ongoing access to CCM patients suffering from moderate to severe heart failure at selected investigational sites until the ...
AMC 083 / UPCC 12716: Tissue Acquisition for Analysis of Prognostic Factors Immunology and Genetic Progression of HIV-1 Associated Malignancies
Please refer to section PROTOCOL SYNOPSIS of the full protocol.
This is a cohort study of women with suspected or confirmed recurrent breast cancer, with accessible tumor by standard clinical biopsy, prior to starting a new therapy for recurrent metastatic disease. Study participants will be ascertained from the population of all persons greater than eighteen years of age receiving care ...
Effect of ramelteon on smoking abstinence
There is a need for novel approaches to optimize smoking cessation treatment to help more smokers quit. Sleep disturbance during nicotine withdrawal may be an important treatment target since existing treatments do not mitigate withdrawal-related sleep disturbance and difficulty sleeping predicts smoking relapse. We hypothesize that the FDA-approved melatonin receptor ...
Stress and Inflammation in Depression
The goal of this study is to understand the effects of inflammation on the aging brain. We want to learn if depression over a person’s lifetime is related to the amount of inflammation in the brain and whether the amount of inflammation in the brain affects treatment response. We also ...
The Effect of Non-Cardiac Mechanisms on Exercise Capacity in Heart Failure Patients.
This proposal will study why people stop exercising. Specifically, it will look at how the skeletal muscles and nerves interact with the heart and lungs during exercise to coordinate the body's response to exercise.The study will enroll individuals with heart failure (both reduced and preserved ejection fraction), patients with hypertension, ...
The Effect of Potassium Nitrate [KNO3] on Exercise Capacity in Heart Failure Patients.
This study will test whether Potassium Nitrate (KNO3) will improve how people with HFpEF [Diastolic Heart Failure] can exercise. In HFpEF, patients are limited in their ability to do all the things they want to do, and exercise as much as they would like, due to becoming tired and short ...
North American Registry for Care and Research in MS - NARCRMS
NARCRMS is a national database that collects patient and physician-based information on MS and will bring together information and data collected in multiple registries and databases across the U.S. and Canada. We expect that data collected consistently over long periods of time, when carefully studied, will 1) produce new clues ...
Quality Improvement Assessment for Patient-Centered Community Health Worker Intervention
The purpose of the IMPaCT Transitions program is to help low-income general medicine patients who have been cared for at the Hospital of the University of Pennsylvania or Presbyterian Hospital with the transition from hospital to a primary care clinic. The purpose of IMPaCT Home is to help low-SES patients ...
A Phase 3 trial to evaluate the safety and efficacy of Eculizumab in the treatment of relapsing NMO. Target population must be 18 years and older, have a confirmed diagnosis of relapsing NMO, and have an EDSS score less than or equal to 7.