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Found 15 Rheumatology trials

A listing of Rheumatology medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

 XCI Maintenance in Scleroderma and Related Female-Biased Diseases

XCI Maintenance in Scleroderma and Related Female-Biased Diseases

35-90 years
All genders
The research study is being done to understand both why and how scleroderma and related female-biased diseases affect women and men differently.  Though we do not know what causes these diseases, we do know that women are much more likely to develop them than men.  We are studying how the …

The COvid19 VaccinE Response in Rheumatology Patients (COVER)

All genders
This study is designed to evaluate the efficacy and safety of SARS-CoV-2 vaccines in patients with autoimmune conditions and to evaluate the impact of different immunomodulatory therapies on vaccine response. Adults with psoriatic arthritis (PsA), axial spondyloarthritis (SpA) and rheumatoid arthritis (RA) will be enrolled. The study involves data and …
 Study to Evaluate Nipocalimab in Participants with Active Idiopathic Inflammatory Myopathies

Study to Evaluate Nipocalimab in Participants with Active Idiopathic Inflammatory Myopathies

18-90 years
All genders
Phase 2
Interventional
The purpose of this study is to see if the investigational drug nipocalimab is safe and useful for treating patients with active Idiopathic Inflammatory Myopathies (IIM).  Another purpose is to find out if nipocalimab can cause side effects, which are unexpected or unwanted reactions from taking a drug.   An …

A randomized double-blind placebo controlled 3-arm multicenter phase 3 study to assess the efficacy and safety of ianalumab in patients with active Sjogren's syndrome (NEPTUNUS-2)

All genders
Phase 3
This is a 52 wk, randomized, double-blind study to demonstarte the clinical efficacy, safety, and tolerability of ianalumab compared to placebo in patients with active Sjogren's syndrome. Pts will receive a subcutaneous injection of ianalumab/placebo monthly, in addition to salivary flow assessments, blood and urine sampling, PROs, and optional assessments …

TWINSS extension

All genders
This is a 1-year extension to the core TWINSS study, open only to eligible participants from the core study who, in the opinion of the Investigator, may potentially derive clinical benefit from continued administration of CFZ533 (iscalimab). The purpose is to provide additional safety and tolerability information and further explore …

Low-Dose Naltrexone to Improve Physical Health in Patients with Vasculitis (LoDoNaVasc)

18-90 years
All genders
Phase 2
The purpose of this study is to see whether a drug called naltrexone improves health-related quality of life in patients with vasculitis. Naltrexone is a prescription drug approved for a different reason at a higher dose than the dose used in this study. However, “low dose naltrexone” is widely used, …
 A Randomized  Double-blind  Placebo-controlled  Repeat-dose  Multicenter Trial to Evaluate the Efficacy  Safety  Tolerability and Pharmacokinetics of HZN-825 in Patients with Diffuse Cutaneous Systemic Sclerosis

A Randomized Double-blind Placebo-controlled Repeat-dose Multicenter Trial to Evaluate the Efficacy Safety Tolerability and Pharmacokinetics of HZN-825 in Patients with Diffuse Cutaneous Systemic Sclerosis

18-90 years
All genders
Phase 3
Normal 0 false false false EN-US X-NONE X-NONE The main purpose of this study is to understand how patients with diffuse cutaneous systemic sclerosis (dcSSc) respond to an investigational drug called HZN-825. The study drug is being tested to determine if it will work and be safe for the treatment …

PAMPA Study

All genders
The primary objective of our proposed trial will be to test the hypothesis that a prolonged, unresolved skin inflammation coupled with musculoskeletal power-doppler ultrasound (MSKPDUS) abnormalities driven by IL-23 increase the risk for transition into PsA and that an intervention that targets one of these pivotal molecules (i.e., Guselkumab) will: …

PRRR

All genders
See Section 2 of protocol See Section 2 of protocol See Section 2 of protocol

ELLIPSS

All genders
The purpose of this study is to better understand molecular pathways and joint destruction in patients with autoimmune diseases such as Psoriatic Arthritis (PsA).
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