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Found 28 Pain trials

A listing of Pain medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

 Investigational COVID-19 Vaccine Trial

Investigational COVID-19 Vaccine Trial

18-60 years
All genders
Phase 1
This clinical research trial is being conducted to find out whether the administration of two investigational dMab products (not approved by the US FDA) with an investigational device is safe, tolerated, and can produce enough antibodies in your blood that may indicate the ability to prevent infection of COVID-19.

Prescribed opioid induced brain damage in chronic pain patients

18-50 years
All genders
Opioids activate the limbic system and results in acute cell injury hippocampal atrophy. Thespecific aims of this proposal are to test the hypotheses that humans with chronic pain on longterm,high-dose opioids: 1. Will demonstrate smaller hippocampal volumes by MRI. 2. Willperform more poorly on neuropsychological tests of memory and associated …
 Pilot Study of a Multi-System Analysis of Opioid Receptor Binding

Pilot Study of a Multi-System Analysis of Opioid Receptor Binding

18-50 years
All genders
The purpose of this research is to learn more about mu opioid receptor (MOR) binding in the brain and body. This study will enroll up to 60 adults in three cohorts of up to 20 participants each: Cohort 1: Subjects with a lifetime diagnosis of Opioid Use Disorder (OUD) on …
 Efficacy and mechanisms of virtual reality treatment of phantom leg pain

Efficacy and mechanisms of virtual reality treatment of phantom leg pain

All genders
Some amputee experience "phantom limb" (PL), a persistent feeling of the missing limb, which is often associated with experience pain (PLP). We will contrast the efficacy of two virtual reality treatments: a Distractor treatment, consisting in a virtual reality (VR) experience that does not require leg movement, and an Active …
 Towards predicting the analgesic response to ibuprofen following third-molar extraction

Towards predicting the analgesic response to ibuprofen following third-molar extraction

18-64 years
All genders
NSAIDs like ibuprofen are pain relievers that are commonly used to reduce pain after dental procedures.  Patients who have their impacted third molar teeth taken out usually experience pain one to three hours after surgery and require pain relievers for at least 2 days. Most people (about 70-90%) experience good …

Neurosensory Abnormalities in SymptomAtic Ocular Surface Patients

All genders
Primary Objectives: 1. To establish the prevalence of neuropathic corneal pain in patients with ocular surface discomfort. 2. To assess the overlap of neuropathic corneal pain with dry eye disease in patients in diseases that are currently thought to be mutually exclusive. 3. To establish the prevalence of subtypes of …

Pharmacogenetic-guided choice of post-surgery analgesics

All genders
1. To determine the feasibility of integrating a PGx panel test in the EMR with a pharmacist PGx e-consult. 2. Determine the fidelity to genotype-guided pharmacotherapy recommendations. 3. To determine if PGx testing will improve the patient self-reported numeric pain scores 4. To determine if PGx testing will reduce MME …

A Phase 2a/b Randomized Double-blind Placebo-controlled Parallel Group Multicenter Clinical Study to Evaluate the Efficacy and Safety of OG-6219 in 3 Dose Levels in Women 18 to 49 Years of Age with Moderate to Severe Endometriosis-related Pain

All genders
A study to investigate efficacy and safety of OG-6219 BID in 3 dose levels compared with Placebo in participants aged 18 to 49 with moderate to severe endometriosis-related pain

Effects of Phloroglucinol vs. Placebo on IBS-D (Irritable Bowel Syndrome- Predominant Diarrhea)

18-99 years
All genders
Phase 2
To evaluate the clinical response of multiple dose strengths of CIN-103 relative to placebo on abdominal pain and stool consistency (as a composite responder) in subjects with IBS-D (Irritable Bowel Syndrome Prominently Diarrhea) over 12 weeks of treatment and the safety and tolerability of multiple dose strengths of CIN-103 relative …

A Randomized Controlled Trial of Robotic versus Open Radical Hysterectomy for Cervical Cancer (ROCC trial)

Female
The purpose of this study is to investigate if minimally invasive surgery, called robotic assisted laparoscopy (small incision surgery), is better or worse than open surgery (otherwise known as a laparotomy) when performing a radical hysterectomy for cervical cancer. A radical hysterectomy is surgery to remove the uterus, cervix, the …
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