Found 17 Ophthalmology trials
A listing of Ophthalmology medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
PPS Study- Screening and Classification of Pentosan-Associated Maculopathy in Patients with Interstitial Cystitis
The primary objective of this study is to determine the prevalence of retinal changes in patients using pentosan polysulfate sodium (PPS) for treatment of interstitial cystitis and further characterize this condition using multimodal imaging. Additionally, this study aims to identify additional clinical findings associated with PPS maculopathy and to gain …
Study to Evaluate the Safety and Efficacy of CSB-001 Ophthalmic Solution 0.1% in Stage 2 and 3 Neurotrophic Keratitis Subjects
Phase 1
The purpose of this study is to compare the safety and effectiveness of the study product, CSB-001 ophthalmic solution 0.1% to placebo when treating stage 2 and 3 Neurotrophic Keratitis.
NAC Attack: Phase III Multicenter Randomized Parallel Double Masked Placebo-Controlled Study Evaluating the Efficacy and Safety of Oral N-Acetylcysteine in Patients with Retinitis Pigmentosa
Phase 3
Currently, this study is recruiting among patients at Penn Medicine. It is not accepting non-Penn Medicine patient participants.The objective of the study will be to evaluate the efficacy and safety of oral N-acetylcysteine (NAC) in patients with retinitis pigmentosa (RP). The study is a multi-center, randomized, placebo-controlled study where adult …
DEFENDO Long-Term Follow-up Study
The purpose of this study is to evaluate the long-term safety and efficacy of Oxervate 0.002% (20 mcg/mL) cenegermin-bkbj ophthalmic solution in Stage 1 Neurotrophic Keratitis patients who enrolled in the DEFENDO study.
Safety and Tolerability of Subretinal OPGx-001 for LCA5-Associated Inherited Retinal Degeneration (LCA5-IRD)
To evaluate the safety and tolerability of OPGx-001 administered via subretinal injection to one eye (treated eye) of participants with LCA5-IRD. The safety and tolerability as assessed by: 1. Number of dose limiting toxicity (DLT) events at the proposed doses 2. Number of procedure-related adverse events (AEs) 3. Number and …
GP44729
The purpose of this study is to assess the efficacy, safety, pharmacokinetics, and pharmacodynamics of subcutaneous satralizumab, a recombinant, humanized antiinterleukin-6 (IL-6) receptor monoclonal antibody, in participants with moderate-to-severe thyroid eye disease (TED).
RGX-314-3101
This phase 3, partially masked, randomized, multicenter study will include 2 periods: an Active Run-in Period (ie, Screening) and an Assessment Period. Participants who receive RGX-314 will be provided the opportunity to enroll into a long-term follow-up (LTFU) study (RGX-314-5101) after completion of or early discontinuation from this current study …
GVRI biomarker study 2021
Nearly 20% of children with Neurofibromatosis type 1 (NF1) will develop an optic pathway glioma (OPG), a low-grade glioma that involves one or more structures of the anterior visual pathway (AVP, i.e., optic nerves, optic chiasm and optic tracts). OPGs can cause permanent vision loss which has a significant impact …
Amber
A randomized, multicenter, double-masked, vehicle-controlled study to evaluate the safety and efficacy of NEXAGON in subjects with PCED. Will enroll 120 subjects. Those subjects whose defect has not re-epithelialized upon end of the Treatment Period or who achieved re-epithelialization but failed to maintain re-epithelialized for 28 days after treatment completion …
PR disease in IRD - Prospective
PURPOSE Record retinal structure with imaging, record visual function, assess change over time and develop a model to predict photoreceptor vulnerability in heterogeneous transition zones of the retina in patients with biallelic ABCA4 mutations and clinical diagnoses of either Stargardt Disease or Cone-Rod Dystrophy. See section 2 'Study Objectives and …
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