Found 70 Neurology trials
A listing of Neurology medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
A Open-Label Ascending Dose Study to Evaluate the Safety and Effects of PR001A in Patients With Parkinson's Disease
Phase 1
This is a 5 year study and the purpose is to assess the safety and tolerability of 2 dose levels of PR001A administered via l injection in patients with moderate to severe Parkinson's Disease
A Randomized Study to Evaluate the Efficacy and Safety of ION-682884 in Patients with Hereditary Transthyretin-Mediated Amyloid Polyneuropathy
Phase 3
A Phase 3 Global, Open-Label, Randomized Study to Evaluate the Efficacy and Safety of ION-682884 in Patients with Hereditary Transthyretin-Mediated Amyloid Polyneuropathy. For those with : a. Stage 1 or Stage 2 according to the Familial Amyloid Polyneuropathy (FAP) or Coutinho Stage b. Documented genetic mutation in the TTR gene …
Advanced Neuroimaging in Multiple Sclerosis
MS is a life-long disease that can clinically manifest at a wide range of ages. Lesions in the white matter of the brain can be found at any age in MS patients. How these lesions may affect functioning of the brain is an area we aim to explore. Although connections …
Healey ALS Platform Trial - Regimen F ABBV-CLS-7262
Phase 2
ABBV-CLS-7262 is a prodrug that is converted in vivo to the pharmacologically active parent compound A-1684909. A-1684909 is a central nervous system (CNS)-penetrant, eukaryotic translation initiation factor 2B (eIF2B) activator that attenuates the integrated stress response (ISR), a highly conserved cellular mechanism hypothesized to be important in the pathophysiology of …
A Study to Evaluate Efficacy and Safety of Treatment With Lecanemab in Participants With Preclinical Alzheimer's Disease and Elevated Amyloid and Also in Participants With Early Preclinical Alzheimer's Disease and Intermediate Amyloid
Phase 3
The Study is two research trials aimed at preventing Alzheimer’s disease (AD) dementia. One is called AHEAD-3 and the other is called AHEAD-45. AHEAD-3 studies people with intermediate amyloid, while AHEAD-45 studies people with elevated amyloid. Research studies are designed to gain scientific knowledge that may help people in the …
University of Pennsylvania Centralized Observational Research Repository on Neurodegenerative Disease
The aim of this study is to create a repository of both cross-sectional and longitudinal data, imaging and biological specimens for neurodegenerative disease research.
Improving Sleep in the Neurology In-Patient Population
The research is being conducted to improve sleep in the inpatient neurology population by decreasing overnight interruptions and addressing environmental barriers to sleep in the hospital. If you agree to join this study, you will be asked to complete the following research procedures: wear an activity and sleep monitor (FitBit), …
To identify reliable markers of LRRK2 activity in human CSF.
The purpose of this research study is to evaluate new tests for Parkinson's disease (PD) that may help in developing better treatments.
HELIOS- A:A Study to Evaluate the Efficacy and Safety of ALN-TTRSC02 in Patients with Hereditary Transthyretin Amyloidosis (hATTR Amyloidosis)
Phase 3
The purpose of this study is to evaluate the efficacy and safety of vutrisiran (ALN-TTRSC02) in patients with hereditary transthyretin amyloidosis (hATTR amyloidosis). Participants will receive vutrisiran or the reference comparator patisiran during the Treatment Period.
Upregulating action semantics to facilitate naming in aphasia
Phase 1
The goal of this research is to improve the likelihood of aphasia treatment success by activating brain networks that can compensate for language impairment. We will use non-invasive brain stimulation and gesture-priming paradigms to encourage activation of action knowledge (semantics), which we predict will in turn boost verb retrieval. We …
