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Found 9 Menopause trials

A listing of Menopause medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Investigation of Social and Circadian Rhythm Dysregulation in the Development of Depression Symptoms During the Menopause Transition

45-52 years
Healthy Volunteer
Female
The purpose of this study is to examine how depression symptoms develop when women begin the transition to menopause. This study will investigate depression symptoms by looking at how fluctuations in reproductive hormones (specifically, the hormone estradiol) might impact the body's biological sleep rhythms. This study will also look at …
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A Double-Blinded Randomized Crossover Trial of Stereoencephalography-Guided Multi-Lead Deep Brain Stimulation for Treatment-Refractory Obsessive Compulsive Disorder (SEEG-Guided DBS for OCD)

22-75 years
All genders
Phase 1
This dual-site, double-blinded, randomized, sham-controlled, crossover study is to assess the safety, feasibility, and preliminary efficacy of SEEG-guided multi-lead DBS in 10 participants suffering from severe symptoms of chronic, treatment-refractory OCD. Stage 1: Invasive SEEG Monitoring and Recovery Goal: To perform stimulation mapping studies and SEEG recordings, that aid in …
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Randomized Blinded Discontinuation Trial of Ocrelizumab in Early Relapsing Multiple Sclerosis

All genders
Phase 4
The primary study objective is to evaluate the rate of durable remission of relapsing disease activity, assessed serially both clinically and by MRI, from randomization through 48 months in participants with early relapsing multiple sclerosis who discontinue OCR after 12 and 24 months of treatment. Secondary objectives include: - Mechanistic: …
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EA1151

All genders
In this trial, women will be randomized to screening with Breast Tomosynthesis(TM) or Digital Mammography (DM). The frequency and number of screening examinations will vary with their menopausal status and whether they have breast cancer risk factors. All premenopausal women will undergo annual screening. Postmenopausal women will undergo biennial screening …
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TRIDENT 2.0

All genders
Primary Objective --To evaluate the hypothesis that the SGLT2 inhibitor, dapagliflozin, alters kidney molecular pathways associated with progression of diabetic kidney disease Secondary Objectives --To evaluate relationships between changes in kidney molecular fingerprints and changes in kidney function --To identify factors associated with changes in kidney molecular fingerprints --To evaluate …
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Cartesian MG-001

All genders
Please refer to section 3 of the study protocol. Penn will only enroll participants into Part 3 of the study. PRIMARY OBJECTIVES The primary objective of Part 1 is to assess the safety, tolerability, and manufacturing feasibility of Descartes-08 in patients with GMG. Part 1 of the study follows an …
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Biohaven Rise 2

All genders
Primary Objective: To compare the efficacy of 2 doses of BHV-7000 to placebo as an adjunctive therapy for refractory focal onset epilepsy as measured by the change from baseline in 28-day average seizure frequency. Secondary Objcetives: -To compare the efficacy of 2 doses of BHV-7000 to placebo as adjunctive therapy …
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GE 280-401

All genders
Primary Objective: a) To measure the proportion of breast cancer patients where Cerianna positron emission tomography (PET)/computed tomography (CT) detection of estrogen receptor (ER) status alters the preexamination intended therapeutic management Secondary Objectives: a) Per subject, to qualitatively assess heterogeneity in tumor Cerianna uptake relative to standard-of-care imaging b) Per …
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An Evaluation of Maintenance Therapy Combination Mirvetuximab Soravtansine and Olaparib (UPROAR)

18-100 years
Female
Phase 2
This study aims to learn more about the use of Mirvetuximab soravtansine and Olaparib as a maintenance therapy after completion of prior therapy for recurrent platinum sensitive ovarian, peritoneal and fallopian tube cancer. Mirvetuximab soravtansine is an effective antibody drug conjugate that targets folate receptor alpha. Olaparib is one of …
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