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Found 59 Lung-disease trials

A listing of Lung-disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

 A study to assess the safety and tolerability of nebulized PC945 for prophylaxis or pre-emptive therapy against pulmonary aspergillosis in lung transplant recipients.

A study to assess the safety and tolerability of nebulized PC945 for prophylaxis or pre-emptive therapy against pulmonary aspergillosis in lung transplant recipients.

18-99 years
All genders
Phase 2
Interventional
The purpose of this study is to learn about how safe and effective a new investigational drug, PC945, can be. An investigational drug is one that is not approved by the United States Food and Drug Administration (FDA). PC945 is an inhaled drug being studied for the prevention of a …

Pilot, Single Center, Feasibility Study of Cuirass Biphasic Ventilator in Chronic Obstructive Pulmonary Disease Patients

21-79 years
All genders
Phase 1
The research study is being conducted to learn about the work of breathing support that an external breathing support device can provide compared to a person’s baseline ability. The research study is sponsored by RightAir Inc, the makers of the device being investigated, the AIR-AD cuirass ventilator. This study is …

DNA Evaluation of Fragments for Early Interception - Lung Cancer Training Study

50-99 years
All genders
Interventional
The purpose of this study is to collect blood samples to determine if a blood-based test can be used to identify lung cancers that may or may not also be seen on images of lungs. Additionally, the study aims to see if a blood-based test can identify other types of …

Pragmatic Clinical Trial Comparing Smoking Cessation Interventions among Underserved Patients who are referred for Lung Cancer Screening

All genders
Phase 3
Low-dose computed tomography (LDCT) screening reduces mortality among current and former smokers at high risk for lung cancer, and is widely recommended by national guidelines. LDCT also increases access to care and thus provides an opportunity to deliver smoking cessation interventions to current smokers in conjunction with this screening. As …

Assessing Drug Epetraborole in Patients with Mycobacterium avium Complex Lung Disease (MACrO2)

18-99 years
All genders
Interventional
The purpose of this study is to learn about the effects of a study drug, Epetraborole, to assess the efficacy for treating refractory MAC. It will enroll patients over 18 years of age and will include the following: physical exams, CTs, medical history, ECGs, lung function tests, vital signs, safety …

Hyperpolarized xenon functional lung imaging in COPD patients undergoing targeted lung denervation

All genders
For information regarding study objectives, please see section 8 of the attached protocol. In the context of targeted lung denervation (TLD), we expect the most informative aspect of altered lung function to be related to regional ventilation, as well as possibly the timing of regional inhaled/exhaled gas flow with respect …

Lung Transplant Outcomes Group: Tacrolimus

All genders
Using a pilot cohort, we hope to estimate tac PK parameters and conduct simulation studies to support design of a multicenter study to develop and validate a robust post-lung transplant tac population pharmacokinetic (popPK) model. The primary outcome will be the area under the concentration-time curve (AUC), which will provide …

PILOT STUDY TO ASSESS LUNG FUNCTION USING PERFUSION BLOOD VOLUME DUAL ENERGY CT AND 4DCT DERIVED LUNG VENTILATION IMAGING

All genders
The basic premise of this pilot study is to enroll 40 patients over 1.5 years who have Stage III or IV non-small cell lung cancer and are planned for definitive treatment with concurrent chemoradiation when a contrast-enhanced 4DCT is planned. The primary goal is to quantify the reproducibility of lung …

DECAMP 1 PLUS Proposal: Prediction of Lung Cancer Using Noninvasive Biomarkers

18-99 years
All genders
The DECAMP 1 PLUS study will expand on previous early detection studies (DECAMP 1 and 2) to improve the efficiency of the diagnostic evaluation of patients with indeterminate pulmonary nodules. This study will investigate molecular, clinical and imaging features that may distinguish benign versus malignant disease among smokers with indeterminate …
 Cardiotoxicity in Non-metastatic Lung Cancer Patients Treated with Chemoradiation Therapy: A Prospective Longitudinal Cohort

Cardiotoxicity in Non-metastatic Lung Cancer Patients Treated with Chemoradiation Therapy: A Prospective Longitudinal Cohort

All genders
We propose a prospective longitudinal cohort of radiation therapy cardiotoxicity in in patients with locally advanced non-small cell lung cancer treated with definitive chemoradiation. We will enroll patients prior to start of chemoradiation and follow them with echocardiogram, PET/CT stress test, blood draw, and symptoms/activity surveys for 2 years to …
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