Found 14 Inflammation trials
A listing of Inflammation medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Investigational COVID-19 Vaccine Trial
Phase 1
This clinical research trial is being conducted to find out whether the administration of two investigational dMab products (not approved by the US FDA) with an investigational device is safe, tolerated, and can produce enough antibodies in your blood that may indicate the ability to prevent infection of COVID-19.
HERMES: Effects of Ziltivekimab Versus Placebo on Morbidity and Mortality in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction and Systemic Inflammation
Phase 3
This study will determine if ziltivekimab, a monoclonal antibody, can be used to treat people living with heart failure and inflammation. Previous studies showed that ziltivekimab can lower inflammation, which may have a positive effect on heart failure symptoms. The HERMES study will look more into this effect. Also, the …
Evaluate Study Drug ABBV-154 in Subjects with Moderately to Severely Active Crohn's Disease (CD): AIM-CD
The purpose of this study is to see if the study drug ABBV-154 is safe and able to treat subjects with moderately to severely active Crohn's Disease who have an inadequate response to or were intolerant of prior biologics. ABBV-154 is an antibody-drug conjugate, which means it is composed of …
Vessel Wall Enhancement in Giant Cell Arteritis
The research study is being conducted to determine the utility of magnetic resonance imaging (MRI) in identifying inflammation of arteries supplying blood to the head, brain, and eyes, which may be useful in the diagnosis, prognosis, and treatment of giant cell arteritis (GCA; temporal arteritis). Study participants are eligible if …
The Role of the Microbiome in Inter-Individual Variability in NSAID Disposition and Response
Phase 1
Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used in the treatment of pain and inflammation. Mounting evidence indicates that rectal administration of NSAIDs is also effective in preventing pancreatitis following endoscopic retrograde cholangiopancreatography (ERCP) by an unknown mechanism. Alterations in the salivary and fecal microbiome have been observed in patients with …
![Imaging inflammation in individuals with Alcohol Use Disorder: an [18F]NOS study](/media/img/trial_thumbnails/img/siteimg/19_y57mJN5.png)
Imaging inflammation in individuals with Alcohol Use Disorder: an [18F]NOS study
This is a research study for people ages 18-65 to learn more about how regular alcohol use affects inflammation in the brain and other organs. We will study this using a Positron Emission Tomography (PET/CT) scan using a radioactive imaging drug called [18F]NOS. [18F]NOS is an experimental radioactive molecule used …
Clascoterone for Pilonidal Disease
Determine the effect of clascoterone on clinical severity of PSD. Analyze the influence of clascoterone in disease-specific quality of life. Quantify the effect of clascoterone on surgical outcomes and cutaneous inflammation. 1. Medical photography with independent physician scores of PSD clinical severity at weeks 4, 8, and 12 on treatment …
Immunologic Analysis of Thoracic Duct Lymph from MS Patients and Controls
This study aims to investigate the benefits of collecting lymph in addition to blood in patients with multiple sclerosis (MS). It is now well recognized that the central nervous system (CNS) is not as immune privileged as it has been considered. A system of lymphatic drainage has been described both …
Evaluating Study Drug BIIB059 in Participants with Active Subacute Cutaneous Lupus Erythematosus and/or Chronic Cutaneous Lupus Erythematosus with or without Systemic Manifestations and Refractory and/or Intolerant to Antimalarial Therapy (AMETHYST)
Phase 2
The research study is being conducted to investigate if the study drug BIIB059 can reduce disease activity and inflammation in people with active Cutaneous Lupus Erythematosus compared to a placebo. Participants will complete the following research procedures: demography and medical history, previous CLE therapy, SARS-CoV-2 (COVID-19) test, chest X-ray, skin …
PROACTIVE: Study to Evaluate the Efficacy and Safety of PRV-015 in Adult Patients with Non-Responsive Celiac Disease as an Adjunct to a Gluten-free Diet
Phase 2
Approximately 50% of patients with celiac disease have continued symptoms despite at least 12 months of treatment with a gluten free diet. PRV-015, a mAb that blocks IL-15, has been shown to reduce intestinal inflammation and improve clinical symptoms induced by gluten consumption in a previous Phase 2a gluten-challenge study …
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