Found 32 Heart failure trials
A listing of Heart failure medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Human Heart Tissue Protocol
The broad objective of this proposed research protocol is to have heart tissue specimens available to use for studies designed to help us better understand the causes and manifestations of human heart failure. The broad objective of this proposed research protocol is to have heart tissue specimens available to use …
HIS-BUNDLE CORRECTIVE PACING IN HEART FAILURE
The aim is to prospectively evaluate the efficacy and mechanism of benefit of HI-CRT vs. BIV CRT in patients with Right Bundle Brank Block (RBBB). Left Ventricular Ejection Fraction (LVEF) will be assess at 6 months following HIS CRT Vs. BIV CRT implant in Heart Failure patients with RBBB.
Acute Effects of Exogenous Ketone Ester Administration in Heart Failure
Please see section 1 of the full protocol
CLASS-HF: Consistently Assess Signs and Symptoms of Heart Failure
The purpose of this study is to examine the reliability and validity of the New York Heart Association (NYHA) Classification Guide that was developed to assist providers in appropriately assigning a functional class to their patients with heart failure. We will be evaluating the NYHA Classification guide against the 6-minute …
Parasympathetic Augmentation via Respiratory Training for Patients with Systolic Heart Failure
Phase 4
The purpose of this study is to evaluate the effect of breath training on patients with systolic heart failure. The study evaluates patients and incorporates the use of smart phone technology for breath training at baseline and at three and six months, using the 6-minute walk test, a standard heart …
Assessment of the CARILLON Mitral Contour System in Treating Functional Mitral Regurgitation Associated with Heart Failure
Prospective, randomized, blinded clinical trial is to assess the safety and efficacy of the CARILLON Mitral Contour System in treating functional mitral regurgitation associated with heart failure.
FACT-CRT: Factors Associated with Response to Cardiac Resynchronization Therapy in Heart Failure Patients with Non-LBBB ECG Pattern
This research study seeks to validate how echocardiogram (echo) data predicts response to cardiac resynchronization therapy (CRT) provided by a CRT device with a defibrillator (CRT-D) in individuals without the heart arrhythmia abnormality left bundle branch block (LBBB). It also aims to identify new variables recorded from electrocardiograms (ECG) or …
HERMES: Effects of Ziltivekimab Versus Placebo on Morbidity and Mortality in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction and Systemic Inflammation
Phase 3
This study will determine if ziltivekimab, a monoclonal antibody, can be used to treat people living with heart failure and inflammation. Previous studies showed that ziltivekimab can lower inflammation, which may have a positive effect on heart failure symptoms. The HERMES study will look more into this effect. Also, the …
THE COMPARATIVE EFFECTIVENESS OF 7 VERSUS 21 HOME-DELIVERED MEDICALLY TAILORED MEALS TO IMPROVE MALNUTRITION RISK IN MALNOURISHED PATIENTS WITH HEART FAILURE: A RANDOM ORDER CROSSOVER FEEDING TRIAL (MEDIMEALS)
The objectives of the random order crossover design study are to compare the effectiveness of 7- versus 21- meals/week on the primary outcome of malnutrition risk score and secondary outcomes of unplanned emergency department visits or hospital readmissions and on diet quality. The primary outcome is the malnutrition risk score …
OPTIMIZER PAS: Post Approval Study (PAS) of the OPTIMIZER Smart and CCM Therapy (PAS)
The OPTIMIZER Smart Post-Approval Study (PAS) is a single arm open label study of 620 participants receiving an OPTIMIZER implant as standard of care. Patients to be included will have NYHA functional class III symptoms and a left ventricular ejection fraction of 25-45%.
