Effect of Organic Nitrates and Hydralazine on Wave Reflections and Left Ventricular Structure and Function in Heart Failure with Preserved Ejection Fraction
The purpose of this study is to test the effect of prolonged therapy (24 weeks) with isosorbide dinitrate ± hydralazine on arterial wave reflections, exercise capacity, left ventricular (LV) mass/fibrosis and diastolic function in patients with Heart Failure and Preserved Ejection Fraction (HFPEF). This is a double-blind, placebo-controlled pilot randomized ...
AdaptResponse Clinical Investigation Plan
The purpose of the research study is looking at a new algorithm (step by step approach) for patients with heart failure who are indicated for an BiV (biventricular) pacing device.
Percutaneous Ventricular Restoration in Chronic Heart Failure due to Ischemic Heart Disease
This is a study of the Parachute Implant device in patients with heart failure. Patients in this study will be those with heart failure due to coronary artery disease. The patients will be randomly assigned to receive the implant device or to receive continued medical management for their heart condition. ...
Oral Iron Repletion effects ON Oxygen UpTake in Heart Failure: IRONOUT-HF
IRONOUT-HF is a multi-center, randomized, double-blinded, placebo-controlled superiority trial of oral Fe polysaccharide compared to matching placebo with the primary endpoint of change in peak VO2 measured by CPET at 16 weeks.
REmission from Stage D Heart Failure (RESTAGE-HF)
This is a non-randomized, prospective, multi-center study. Forty subjects satisfying the inclusion and exclusion criteria listed below will be recruited at participating centers. Subjects will be recruited to the trial in a preliminary manner prior to LVAD implantation or within 4 weeks of LVAD implantation. Subjects will be followed for ...
RANDOMIZED EVALUATION OF VAD INTERVENTION BEFORE INOTROPIC THERAPY
REVIVE-IT is a two-part study consisting of a trial and a registry. The REVIVE-IT Trial is a prospective, randomized, open-label, multicenter trial, evaluating the HeartMate II® LVAS versus a control group consisting of optimal medical management (OMM) in selected non-inotrope dependent, ambulatory, moderately advanced heart failure patients who are not ...
Attain StarFix Model 4195 LV Lead Extraction Study
The purpose of this study is to characterize the removability of the Attain StarFix®Model 4195 Left Ventricular (LV) Lead (StarFix®). The goal of the trial is to evaluate the lead removal success in patients that are indicated for left ventricular lead removal. This study is required by the Food and ...
The Effect of Potassium Nitrate [KNO3] on Exercise Capacity in Heart Failure Patients.
This study will test whether Potassium Nitrate (KNO3) will improve how people with HFpEF [Diastolic Heart Failure] can exercise. In HFpEF, patients are limited in their ability to do all the things they want to do, and exercise as much as they would like, due to becoming tired and short ...
The Effect of Non-Cardiac Mechanisms on Exercise Capacity in Heart Failure Patients.
This proposal will study why people stop exercising. Specifically, it will look at how the skeletal muscles and nerves interact with the heart and lungs during exercise to coordinate the body's response to exercise.The study will enroll individuals with heart failure (both reduced and preserved ejection fraction), patients with hypertension, ...
The Medical Arm of Mechanical Circulatory Support (MedaMACS) Study
The MedaMACS Pilot Study is a prospective, observational study of ambulatory patients with advanced heart failure. The study will enroll patients who have not yet received an LVAD but who receive their care at a hospital with a JCAHO-certified mechanical circulatory support program.