Found 7 Cystic-fibrosis trials
A listing of Cystic-fibrosis medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Cystic Fibrosis Microbiome
Among lung transplant recipients who survive to 5 years, half suffer from chronic lung allograft dysfunction (CLAD). This study will evaluate how changes in the lung microbiome may cause CLAD in Cystic Fibrosis patients who have been transplanted. This is a case-control study of Cystic Fibrosis lung transplant recipients to …
Effect of GLP-1 Agonist Therapy on Insulin Secretion in Adults with Pancreatic Insufficient Cystic Fibrosis and Abnormal Glucose Tolerance: a randomized open-label cross-over trial
Diabetes is a major co-morbidity in pancreatic insufficient cystic fibrosis (PI-CF) and associated with worse outcomes. While reduced -cell mass contributes to the insulin secretory defects that characterizes cystic fibrosis-related diabetes (CFRD), other modifiable determinants appear operative in the emergence and progression of abnormal glucose tolerance towards diabetes. Identifying interventions …
ASPEN- A Phase 3 Randomized Double-Blind Placebo-Controlled Study to Assess the Efficacy Safety and Tolerability of Brensocatib Administered Once Daily for 52 Weeks in Subjects With Non-Cystic Fibrosis Bronchiectasis
Phase 3
Penn Medicine patients already participating in protocol INS1007 301 will be invited to participate in this study. The Pharmacokinetic (PK) portion of this substudy is designed to evaluate the amount of brensocatib present in your blood at certain time periods before and after the study drug is administered, and the …
[18F]FLUOROPROPYL-TRIMETHOPRIM (F-TMP) PET/CT IMAGING TO EVALUATE BIODISTRIBUTION AND KINETICS IN HUMAN SUBJECTS
Phase 1
Patients with known or suspected bacterial infection at the time screening are eligible for this study. Patients may participate in this study if they are at least 18 years of age, and most participants will be receiving care at the clinical practices of the University of Pennsylvania. Up to 20 …
Study Evaluating Maternal and FetaL Outcomes in the ERA of ModulatorS (MAYFLOWERS)
The purpose of any research study is to answer questions. The MAYFLOWERS study is being done to look at how pregnancy affects the health of women with cystic fibrosis (CF) and to look at the health of babies born to women with CF. It is expected that most but not …
RESPIRION-102
The main purpose of this study is to see whether inhaling this combination of drugs in RSP-1502 has an acceptable safety profile and works better compared to inhaling tobramycin alone when treating participants with Cystic Fibrosis and chronic Pseudomonas aeruginosa lung infection. Procedures include spirometry, ECG, sputum collection, and pharmacokinetic …
4DMT
The objectives of this Phase 1/2 prospective interventional trial are to: 1. Evaluate the safety, tolerability, and immunogenicity of a single dose of 4D-710 delivered via nebulization 2. Identify a recommended phase 2 dose (RP2D) for further evaluation 3. Evaluate 4D-710 target gene transduction/expression in bronchoscopic samples (Dose Exploration) and …
