Three Approaches to Maintenance Therapy for Chronic Insomnia in Older Adults
Do you have trouble falling asleep or staying asleep 3 or more nights per week? Have you had trouble sleeping for more than 6 months? Are you between the ages of 60-85? If so, you may be eligible to participate in a research study evaluating a novel way to utilize ...
Neural Mechanisms Underlying the Antidepressant Effects of Sleep Deprivation
It has long been known that sleep deprivation improves mood in 50-60% of people with depression but it is not known how this works in the brain. The purpose of this study is to better understand how one night of sleep deprivation affects mood in people with depression using brain ...
Pharmacogenetic Study of the medication Ondansetron in Alcohol Use Disorder
The primary study objective is to determine the efficacy of ondansetron (0.33 mg twice daily) administered orally for a period of 16 weeks in reducing risky drinking among currently drinking African American subjects with Alcohol Use Disorder who have selected genotypes at the serotonin transporter and receptor genes. The secondary ...
Brain and behavioral effect of tobacco labeling and packaging on adolescents at risk for nicotine dependence
The University of Pennsylvania is conducting a study of brain responses to graphic health warnings. The study includes receiving cell phone messages for 4 weeks and two functional Magnetic Resonance Imaging (fMRI) scans of the brain. These scans are non-invasive and do not use X-ray. To be eligible to participate, ...
Weight History, Brain Activation to Food Cues and Eating Disorder Psychopathology
Drexel University and the University of Pennsylvania seek women exhibiting eating disordered behaviors for studies funded by NIH. Studies examine biological, neurological, and behavioral factors contributing to eating problems. Eligible participants attend four to five visits over six months. Compensation is provided. Call 215-762-1313 or e-mail DUeatingdisorders@drexel.edu
Effect of ramelteon on smoking abstinence
There is a need for novel approaches to optimize smoking cessation treatment to help more smokers quit. Sleep disturbance during nicotine withdrawal may be an important treatment target since existing treatments do not mitigate withdrawal-related sleep disturbance and difficulty sleeping predicts smoking relapse. We hypothesize that the FDA-approved melatonin receptor ...
A brief treatment on PTSD symptoms in pregnancy
We are looking for women to participate in a research study on psychotherapy for symptoms of Post-Traumatic Stress Disorder (PTSD) during pregnancy. The study will involve: screening questionnaires and a baseline visit to determine eligibility; Participation in a computer based stress task; Four weekly visits (30-45 minutes) with a psychologist ...
A Randomized, Double-blind, Active-controlled Trial to Assess the Efficacy and Safety of AXS-05 Administered Orally to Subjects with Treatment Resistant Major Depressive Disorder
We are currently enrolling participants for a clinical research study to look at the effectiveness and safety of an investigational medication AXS-05 (a combination of bupropion and dextromethorphan) compared to bupropion (Approved by FDA), in patients with depression who have not responded to prior treatment with at least one antidepressant. ...
Hormone effects in smoking addiction
The purpose of this study is to determine whether progesterone is helpful in reducing withdrawal symptoms, cigarette cravings, and smoking behavior. This study will also use brain imaging to measure the possible effects of progesterone on your brain chemicals. Healthy male and non-pregnant female smokers are invited to screen for ...
401 Study: Trial of Assessing the Efficacy and Safety of ITI-007 Monotherapy in the Treatment of Patients with Major Depressive Episodes Associated with Bipolar I or Bipolar II Disorder (Bipolar Depression)
We are looking for people who are currently experiencing major depressive episodes associated with bipolar I or bipolar II disorder to take part in our bipolar depression studies. These clinical research studies are designed to help us learn more about an investigational medication for symptoms of bipolar depression.