Comparing Effectiveness of Aripiprazole Augmentation, rTMS Augmentation, and Switching to Venlafaxine XR in Treatment Resistant Depression (ASCERTAIN-TRD)
This is a multi-site, randomized, open-label, to compare the efficacy of aripiprazole augmentation, rTMS augmentation, and switching to venlafaxine XR as treatments for treatment-resistant depression.
A Study to Evaluate the Efficacy and Safety of Adjunctive Pimavanserin in Major Depressive Disorder
This is a multicenter, randomized, double-blind, placebo-controlled study to assess the efficacy of pimavanserin compared to placebo when given adjunctively to a selective serotonin reuptake inhibitor (SSRI)/serotoninnorepinephrine reuptake inhibitor (SNRI) antidepressant as treatment of patients with Major Depressive Disorder (MDD) who had inadequate response to antidepressant therapy.
Hormone effects in smoking addiction
Healthy male and non-pregnant female smokers are invited to screen for study participation in a protocol examining the effect of the hormone progesterone on smoking cravings.
Treatment for cocaine dependence
A PHASE II, DOUBLE-BLIND, PLACEBO-CONTROLLED, TRIAL OF NS2359 FOR THE TREATMENT OF COCAINE DEPENDENCE If you suffer from cocaine dependence, a new clinical research study is available for you. The purpose of this research study is to test whether the drug, NS2359, is useful and safe for treating cocaine dependence.
401 Study: Trial of Assessing the Efficacy and Safety of ITI-007 Monotherapy in the Treatment of Patients with Major Depressive Episodes Associated with Bipolar I or Bipolar II Disorder (Bipolar Depression)
We are looking for people who are currently experiencing major depressive episodes associated with bipolar I or bipolar II disorder to take part in our bipolar depression studies. These clinical research studies are designed to help us learn more about an investigational medication for symptoms of bipolar depression.
DREAM - Disease Recovery Evaluation and Modification Study
This is a study to test a new way of taking a medication. The purpose of this study is to help understand if monthly injectable medication [paliperidone palmitate (Invega®]) or oral antipsychotic medication is better at preventing symptoms of schizophrenia or schizophreniform disorder from getting worse. During the study you ...
Trial of Rapid-acting Intranasal Esketamine for Treatment-resistant Major Depressive Disorder (TRANSFORM-2)
We are currently enrolling participants for a clinical research study to look at the effectiveness and safety of an investigational medication (given as a nasal spray) in patients with depression who have not responded to prior treatment with at least two antidepressants. If you are eligible for this study and ...
Interaction of Estrogen and Serotonin in Modulating Brain Activity in Menopause
The purpose of the study is to look at the relationship between different types of early life issues and how your brain functions as an adult. There is some evidence to show that early life stress can lead to many different types of health outcomes as an adult such as ...
Investigating the Impact of Childhood Adversity on Brain Activity in Post-Menopausal Women
The aim of this study is to further our understanding of the impact of prepubertal adverse childhood experiences on brain activation during performance of affective and cognitive processing and memory tasks in men post-menopausal women between the ages of 48 and 65. Using functional brain imaging, we will identify differences ...
Startle Response in Women with Premenstrual Mood Disorders
This study examines stress response in women with premenstrual mood changes (PMDs) versus women without PMDs and men. We are looking for women with and without PMDs, and for men. For this study, you will be asked to fill out forms about your physical and mental health, have blood and ...