Three Approaches to Maintenance Therapy for Chronic Insomnia in Older Adults
Do you have trouble falling asleep or staying asleep 3 or more nights per week? Have you had trouble sleeping for more than 6 months? Are you between the ages of 60-85? If so, you may be eligible to participate in a research study evaluating a novel way to utilize ...
Neural Mechanisms Underlying the Antidepressant Effects of Sleep Deprivation
It has long been known that sleep deprivation improves mood in 50-60% of people with depression but it is not known how this works in the brain. The purpose of this study is to better understand how one night of sleep deprivation affects mood in people with depression using brain ...
Pharmacogenetic Study of the medication Ondansetron in Alcohol Use Disorder
The primary study objective is to determine the efficacy of ondansetron (0.33 mg twice daily) administered orally for a period of 16 weeks in reducing risky drinking among currently drinking African American subjects with Alcohol Use Disorder who have selected genotypes at the serotonin transporter and receptor genes. The secondary ...
A Randomized Pharmacogenetic Study of the Medication Topiramate in European-American Heavy Drinkers
This is a 12-week, prospective, randomized clinical trial of the moderating effect of the gene rs2832407 on the efficacy of the medication topiramate in reducing drinking in 200 individuals of European descent with DSM-5 AUD. The investigators will compare the efficacy of topiramate to placebo in reducing drinking.
Brain and behavioral effect of tobacco labeling and packaging on adolescents at risk for nicotine dependence
The University of Pennsylvania is conducting a study of brain responses to graphic health warnings. The study includes receiving cell phone messages for 4 weeks and two functional Magnetic Resonance Imaging (fMRI) scans of the brain. These scans are non-invasive and do not use X-ray. To be eligible to participate, ...
A Study Examining the Effectiveness of an FDA-Approved Medication for the Treatment of Binge Eating Disorder
The 17-week, double-blind, randomized placebo-controlled trial will test the efficacy of an FDA-approved medication, liraglutide 3.0 mg/d, as compared to placebo in reducing the number of binge episodes per week, achieving remission from binge episodes, and in changes in body weight, global BED symptom improvement, and other psychological factors related ...
Weight History, Brain Activation to Food Cues and Eating Disorder Psychopathology
Drexel University and the University of Pennsylvania seek women exhibiting eating disordered behaviors for studies funded by NIH. Studies examine biological, neurological, and behavioral factors contributing to eating problems. Eligible participants attend four to five visits over six months. Compensation is provided. Call 215-762-1313 or e-mail DUeatingdisorders@drexel.edu
Effect of ramelteon on smoking abstinence
There is a need for novel approaches to optimize smoking cessation treatment to help more smokers quit. Sleep disturbance during nicotine withdrawal may be an important treatment target since existing treatments do not mitigate withdrawal-related sleep disturbance and difficulty sleeping predicts smoking relapse. We hypothesize that the FDA-approved melatonin receptor ...
A brief treatment on PTSD symptoms in pregnancy
We are looking for women to participate in a research study on psychotherapy for symptoms of Post-Traumatic Stress Disorder (PTSD) during pregnancy. The study will involve: screening questionnaires and a baseline visit to determine eligibility; Participation in a computer based stress task; Four weekly visits (30-45 minutes) with a psychologist ...
Clinical and Genetic Characteristics of Opioid Addiction in Chronic Pain
The goal of this project is to develop a profile of patients' risk factors for opioid addiction when receiving opioid therapy for chronic pain. This project will investigate various influences in the development of addiction in 2,000 individuals, with history of chronic pain, who have undergone treatment for addiction to ...