ACUTE EFFECTS OF KETONE SUPPLEMENTATION ON SUBJECTIVE AND OBJECTIVE RESPONSES TO ALCOHOL IN HEALTHY VOLUNTEERS

This is a research study to evaluate the immediate subjective and objective effects of alcohol after consuming a ketone supplement beverage, compared to a placebo beverage (an inactive substance). You will not know which lab visit you receive the ketone drink, however you will be asked to drink an alcohol beverage (based on your weight), to bring your breath alcohol concentration (BrAC) to about 0.050% at each lab visit. The ketone supplement (Kenetik, Vitanav inc, Washington DC) is a dietary supplement that has been extensively studied in humans and is designated by the FDA as Generally Recognized as Safe (GRAS). Its use in this study is experimental. The goal of the study is to see how you experience alcohol, once after drinking the ketone supplement and once after drinking a placebo beverage, which will look and taste the same. We will use questionnaires, blood, and breath alcohol tests to see how your body and brain experience alcohol. We are also interested in if the ketone supplement makes you want to drink alcohol more or less.