ACUTE EFFECTS OF KETONE SUPPLEMENTATION ON SUBJECTIVE AND OBJECTIVE RESPONSES TO ALCOHOL IN HEALTHY VOLUNTEERS
Study Overview
This is a research study to evaluate the immediate subjective and objective effects of
alcohol after consuming a ketone supplement beverage, compared to a placebo
beverage (an inactive substance). You will not know which lab visit you receive the
ketone drink, however you will be asked to drink an alcohol beverage (based on your
weight), to bring your breath alcohol concentration (BrAC) to about 0.050% at each lab
visit. The ketone supplement (Kenetik, Vitanav inc, Washington DC) is a dietary
supplement that has been extensively studied in humans and is designated by the FDA
as Generally Recognized as Safe (GRAS). Its use in this study is experimental. The
goal of the study is to see how you experience alcohol, once after drinking the ketone
supplement and once after drinking a placebo beverage, which will look and taste the
same. We will use questionnaires, blood, and breath alcohol tests to see how your body
and brain experience alcohol. We are also interested in if the ketone supplement makes
you want to drink alcohol more or less.
Study Description
If you agree to join the study, you will be asked to complete the following research
procedures:
• A consent/screening visit (2 hours): medical history questionnaire, routine bloodwork,
a urine drug screen, psychological assessments, and questionnaires to
determine eligibility.
• Complete 2 lab visits (approx. 5 1/2 hrs.), during both of which you will receive
about 2 ½ standard alcohol beverages, based on your weight. Also, you will
receive a ketone supplement drink on one visit and a placebo drink on the other
visit. The visits will include alcohol breathalyzers, blood draws, and
questionnaires
Compensation:
• screening visit: $40
• Lab 1: $75
• Lab 2: $100
- Study Identifier: 852002
