Study of Immune Response in Lymph Nodes and Blood following COVID Vaccination or Infection

Brief description of study

The research study is being conducted to study the Immune System, specifically, the immune reactions that take place in lymph nodes following either vaccination or infection. This study will be looking at vaccines and infection related to SARS-CoV-2. Procedures include: Blood draw and Fine Needle Aspiration of cervical (neck) and/or axillary (armpit) lymph nodes. During a fine needle aspiration a small needle is placed in the lymph node in order to collect cells.

Detailed description of study

The Locci lab in the Department of Microbiology, University of Pennsylvania are looking to recruit volunteers for a research study investigating the immune response to SARS-CoV-2 infection and vaccination (IRB identifier: 851259). The purpose of this study is to see how the immune response differs between individuals who have recovered fully from SARS-CoV-2, and those who have developed Long Covid. This study will evaluate the immune responses in the blood and in the lymph nodes.

For the COVID-19 infection study, we are looking to recruit adults aged 18-80 years old who have recently had SARS-CoV-2 infection. Participants will either have made a full recovery or received a diagnosis of Long Covid from their physician. People who have a personal history of cancer, transplant or autoimmune disease, hospitalisation for COVID, or treatment with monoclonal antibody are not eligible for this study.

For the vaccination study, we are looking to recruit adults aged 18-80 years old who are planning on receiving a SARS-CoV-2 vaccine or booster vaccine. People who have a personal history of cancer, transplant or autoimmune disease, hospitalisation for COVID, or treatment with monoclonal antibody are not eligible for this study.

Participation in this study might be for 9 months after SARS-CoV-2 infection or vaccination/booster and will involve up to three visits. At each visit, participants will be asked to have a blood draw and fine needle aspiration of cervical (neck) and/or axillary (armpit) lymph nodes. Each visit will take approximately 2-3 hours, and participants will be re-imbursed $150 per visit. You may opt-out of the study at any time by contacting the lead investigator. This will not affect any ongoing or future treatment.

For further information, please contact the lead investigator Michela Locci (michela.locci@pennmedicine.upenn.edu) or

Hannah Sharpe (Hannah.sharpe@pennmedicine.upenn.edu)

Eligibility of study

You may be eligible for this study if you meet the following criteria:

Conditions:
Medical Research,COVID
Age: Between 18 Years - 80 Years
Gender: All

We are unable to recruit individuals who have: 1. prior hospitalization for COVID 2. Personal history of cancer, transplant, or autoimmune disease 3.
Treated with monoclonal antibody

Updated on 09 Mar 2024. Study ID: 851259

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