Towards Objective Metrics to Quantify the Role of HIV and Increasing Cognitive Demand on Instrumental ADLs in People Aging with HIV

Brief description of study

The objective of this proposal is to examine the utility of a robot-based approach to study instrumental activities of daily living (IADLs) function and cognitive-motor performance in persons aging with HIV. IADLs often require high levels of executive functioning during the performance of motor activities, but there are no good quantitative assessment strategies to capture impairments in IADL function. HIV produces such impairments via accelerated aging and HIV-Associated Neurocognitive Disorders.

We intend on applying these technological advancements to improve health outcomes in individuals dealing with the complex interactions across HIV, aging, and disability. We have developed a series of novel robot-based tasks whose metrics show potential to objectively quantify gross and fine motor impairment in the upper limb as well as cognitive impairment in the executive function domain in older adults living with HIV. Our goal is to determine how these metrics relate to and predict IADL function in older adults with and without HIV and what role HIV plays in the management of motor tasks with increasing cognitive demands.

Detailed description of study

The study activities will take place at Rehabilitation Robotics Lab located at Penn Medicine Rittenhouse at 1800 Lombard Street, Philadelphia, PA 19146.

We are looking for two types of individuals:

1) Participants for our control group: Healthy people without HIV and without brain impairments who are above the age of 50.

2) Participants for our Test group: People with HIV who are above the age of 50.

The study should only take one session of approximately three hours with rest times built in and involves you completing cognitive and motor clinical assessment scales and then using a robot to complete several tasks.

The study pays $50.00 compensation at the end of the session.

Our aims are the following:

Aim 1: To assess a novel robot-based motor and cognitive task with existing clinical tools used to predict motor impairment, cognitive impairment and IADL function in older adults living with HIV. In a cross-sectional study, 21 participants aging with HIV and 21 non-HIV controls with varying levels of motor function will be evaluated using our robot-based gaming and gold standard clinical tests relating to instrumental activities daily living (IADL) function, gross and fine motor function, and executive function.

Aim 2: To assess interactions between increasing cognitive demand and motor performance in older adults living with HIV and controls without HIV. In a cross-sectional study, 36 participants with HIV and 23 matched controls will be evaluated using our novel robot-based gaming task. In this aim, we will vary the cognitive difficulty of the robot-based task and measure changes in motor performance as a function of three levels of task difficulty.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

Conditions:
Healthy,HIV,AIDS
Age: Between 50 Years - 100 Years
Gender: All

Key eligibility requirements:

Older Adults with HIV/AIDS (50 years or older)

on Anti-retroviral treatment

Able to complete tasks

Controls:

Healthy Older Adults (50 years and older)

Updated on 09 Mar 2024. Study ID: 844802

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