FDG/PET study: Relationship between brain and heart glucose metabolism in Alcohol Use Disorder

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Study Overview

The goal of this study is to learn more about how a nutritional supplement “ketone ester” (deltaG) has an effect on brain and heart function and on alcohol consumption in individuals with and without alcohol use disorder. The research team will study this using Fluorodeoxyglucose (FDG) Positron Emission Tomography/Computed Tomography (PET/CT) scans after a single dose of ketone ester and at baseline (no drink).

The duration of the study is up to 8 weeks. The study will take place on the Penn Medicine Center City/ University of Pennsylvania campus.
The research team is looking for 10 individuals with Alcohol Use Disorder, and 10 healthy control participants.
You may be compensated up to $685 for participation till completion of the study.

Study Description

  • If you agree to join the study, you will be asked to complete the following research procedures.
  • Drinking a nutritional supplement ketone ester during one scanning visit.
  • Two FDG-PET/CT scans
  • Two echocardiograms before the FDG-PET/CT scans.
  • An MRI scan of the brain.
  • Blood draws for measurements of glucose or other testing
Contact the research team using the form below, if you are interested and would like to know more. 

Additional Information:

Please read the criteria below. If you think you qualify, are interested and wish to learn more, contact the research team using the form below.
Some of the criteria for Group 2-healthy controls/ non-drinkers include, but not limited to:
Must be:
1. Age 21 years to 65 years old.
2. Participants must agree to not consume alcohol beverages for 24 hours prior to laboratory sessions, and consume less than 15 drinks per month.
3. Must be able to comfortably lie flat on back for approximately 1 hour in the MRI scanner or PET scanner.

  • Study Identifier: 848992

Recruitment Status


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