The Role of the Reproductive Tract Environment, from both Cellular and Molecular perspective, in Recurrent Pregnancy Loss
Brief description of study
This study is being conducted to determine if the microbial and immune environments in the female reproductive tract (vagina, cervix, and uterus) are altered in women who experience recurrent pregnancy loss (RPL), a devastating condition in which women/couples experience multiple miscarriages. This study will help us determine if the bacteria that live in the vagina, cervix and uterus, and the response to those bacteria, are different in women who have recurrent miscarriages
Detailed description of study
For this study, we are asking you to allow us to obtain swabs from your vagina and cervix, as well as a sample of tissue from the lining of your uterus. This sample is called an endometrial biopsy. We will look at this tissue and examine the types of microbes that live there and the types of natural chemicals that are produced there. We will also be obtaining a blood sample (approximately 1 tablespoon) at the time we obtain the swabs and endometrial biopsy.
Eligibility:
Regular periods (every 21-35 days)
Not on birth control
Have had 2+ children OR have a history of 2+ miscarriages
Eligibility of study
You may be eligible for this study if you meet the following criteria:
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Conditions:
Gynecology,Healthy Volunteer
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Age: Between 18 Years - 43 Years
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Gender: Female
Regular periods (every 21-35 days)
Not on birth control
Updated on
31 Mar 2023.
Study ID: 843048
