Effects of Nutritional Ketone Ester on Brain Function and Alcohol Consumption in Alcohol Use Disorder

Effects of Nutritional Ketone Ester on Brain Function and Alcohol Consumption in Alcohol Use Disorder

Brief description of study

The goal of this study is to learn more about how a nutritional supplement “ketone ester” (DeltaG) has an effect on brain function and on alcohol consumption in individuals with alcohol use disorder. We will study this using Magnetic Resonance Imaging (MRI) scans.

Participants will be compensated/reimbursed for their time and effort. Participants may be compensated up to $677 if they complete the main study and the sub-study.

Detailed description of study

The research team is currently seeking 2 groups of participants: drinkers and non-drinkers (control group). Please review the criteria for participation listed in the Additional Information section, before contacting the research team.
 
  • Group 1: 20 participants with alcohol use disorder
  • Group 2: 10 non-drinkers or healthy controls.
Participants that agree and qualify to join the study, will be asked to complete the following research procedures:
  • Drinking a nutritional supplement ketone ester
  • MRI scans of the brain
  • Blood draws for measurements of glucose or other testing
  • Alcohol consumption: we will give you a tray with alcoholic drinks (i.e., vodka mixed with diet soda of your choice) Participants will be asked to come to Penn Medicine 3 times over a period of approximately 4 weeks.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    addictions,alcohol,alcohol use disorder
  • Age: Between 21 Years - 65 Years
  • Gender: All


Updated on 21 Jun 2023. Study ID: 844235

Interested in the study

Select a study center that’s convenient for you, and get in touch with the study team.

Contact a study center