Effects of Nutritional Ketone Ester on Brain Function and Alcohol Consumption in Alcohol Use Disorder

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Study Overview

The goal of this study is to learn more about how a nutritional supplement “ketone ester” (DeltaG) has an effect on brain function and on alcohol consumption in individuals with alcohol use disorder. We will study this using Magnetic Resonance Imaging (MRI) scans.

Participants will be compensated/reimbursed for their time and effort. Participants may be compensated up to $677 if they complete the main study and the sub-study.

Study Description

The research team is currently seeking 2 groups of participants: drinkers and non-drinkers (control group). Please review the criteria for participation listed in the Additional Information section, before contacting the research team.
  • Group 1: 20 participants with alcohol use disorder
  • Group 2: 10 non-drinkers or healthy controls.
Participants that agree and qualify to join the study, will be asked to complete the following research procedures:
  • Drinking a nutritional supplement ketone ester
  • MRI scans of the brain
  • Blood draws for measurements of glucose or other testing
  • Alcohol consumption: we will give you a tray with alcoholic drinks (i.e., vodka mixed with diet soda of your choice) Participants will be asked to come to Penn Medicine 3 times over a period of approximately 4 weeks.

Additional Information:

Please read the criteria below. If you think you qualify, are interested and wish to learn more, contact the research team using the form below.
Some of the criteria for Group 2-healthy controls/ non-drinkers include, but not limited to:
Must be:
1. Age 21 years to 65 years old.
2. Participants must agree to not consume alcohol beverages for 24 hours prior to laboratory sessions, and consume less than 15 drinks per month.
3. Must be able to comfortably lie flat on back for up to 2 hours in the MRI scanner or PET scanner.

  • Study Identifier: 844235

Recruitment Status


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