PET/CT imaging will be used to evaluate neuroinflammation in
subjects with Alzheimer's Disease and Healthy Controls, using the
investigational radiotracers [11C]PBR28 and[18F]NOS. Each subject will
have one PET/CT session that includes both [11C]PBR28 and [18F]NOS
injections and scan of the brain performed sequentially. Subjects may
also undergo a brain MRI if they have not had an adequate MRI within 6
months or 1 year of enrollment.
We plan to enroll adult subjects in this study, patients with a diagnosis of Alzheimer's Disease or mild cognitive impairment (AD cohort) and Healthy Controls (HC cohort) that are part of the UPenn Alzheimer's Disease Center (ADC) research cohort.
Subjects will also have a brain MRI scan if they have not had one within 6 months or 1 year of the PET scan visit.
Study Identifier: 834090
Contact the research team to learn more about this study.