The purpose of this study is to understand how the body learns to fight infections, through influenza vaccination or after SARS-CoV2 infection that causes COVID-19.
After exposure to one of these pathogens or vaccine, the body’s white blood cells, which defend against infections, are mobilized. As the infection is cleared, the immune system is left with memory cells which are able to recognize the pathogen again the next time an infection occurs.
Some details of how memory is formed for antibody production is not completely understood. Better understanding of the establishment of memory cells and antibody responses will help future efforts to develop better vaccines
Blood samples will be needed from individuals who are healthy or from individuals who have recovered from COVID-19 or suspected exposure. Volunteers eligible for this study are least 18 years of age, are not pregnant, and weigh at least 110 pounds.
1. Blood draw: If you decide to participate as a blood donor in this study by signing a consent form, the study team will work with you to find the most convenient time and arrange for a blood draw. Blood draw can occur at the Hospital of the University of Pennsylvania or at your home, by mobile blood draw services.
2. Health Survey (if recovered from COVID-19): If you are considered recovered from COVID-19, you will additionally be asked questions about the timing of your illness and the symptoms you experienced during the illness.
There is no cost to you for participation. There is no compensation for participating in this study