NSAIDs like ibuprofen are pain relievers that are commonly used to reduce pain after dental procedures.
who have their impacted third molar teeth taken out usually experience pain one
to three hours after surgery and require pain relievers for at least 2 days. Most
people (about 70-90%) experience good to excellent relief of their pain when
they take ibuprofen. However, some patients experience only limited pain
relief with ibuprofen, and a few experience no pain relief at all. These
patients need a different type of pain reliever added to their regimen. The purpose
of this study is to see if there are substances in your blood and urine which we
will take both before and after your wisdom teeth surgery that can tell us how
you personally will respond to
ibuprofen in comparison to placebo (an inactive sugar pill). We will also study
how well ibuprofen combined with acetaminophen works for up to 7
days after surgery.
There are 4 study visits:
1) Screening - patients read and sign
informed consent, urine and blood sample are taken, fill out
questionnaire about mood and pain expectations.
2) Surgery - Swab of mouth to
collect bacteria, urine and blood sample taken prior to surgery. Have
surgery performed standard of care, receive study medication (ibuprofen
400 mg or placebo), multiple urine and blood samples (through indwelling
catheter) taken, pain assessments taken, discharged with ibuprofen
400mg/acetaminophen500mg taken q4h and oxycodone 5mg if needed
24 Hour Follow-up - Return visit with a single blood and urine sample
4) Day 7 Follow-up - Return visit with a single blood and urine sample
If you are interested in participating in this study or would like more information, please complete the form below or call Stacey Secreto in the Oral Surgery and Pharmacology Research Unit at 215-746-8871.
Study Identifier: 832417
Contact the research team to learn more about this study.