Changing The Trajectory Of Mild Cognitive Impairment With Cpap Treatment Of Obstructive Sleep Apnea (Memories 2)
Brief Description Of Study
The purpose of the research is to study whether treatment of sleep apnea, using continuous positive airway pressure (CPAP), delays memory decline and preserves everyday function for older adults with mild memory changes.
Detailed Study Description
Sleep apnea is a medical condition that many people do not know they have because it occurs during sleep. Sleep apnea is associated with snoring, pauses in breathing, and drops in oxygen in the brain and blood, and it may affect memory in older adults. The participants in the study with sleep apnea will receive CPAP treatment for sleep apnea. CPAP is a small machine (about the size of a toaster) connected by a tube to a soft plastic mask. The mask is placed over the nose and pressure from the CPAP machine prevents snoring, pauses in breathing, and keeps the oxygen levels high in the brain and blood. The participants who do not have sleep apnea do not need a CPAP machine and thus will not use a CPAP machine. The research study involves participating in research interviews/ questionnaires, a blood sample, MRI, Amyloid PET/CT scans and Lumbar Punctures (optional)
A recent sleep study (within the past year) is required to determine if you do or do not have sleep apnea.
Additional Information About The Study
The study participant and their designated study partner will each receive compensation for participation in this study.
Study Participant Compensation: A considerable time commitment is associated with participation in this study. You will be reimbursed for the time you spend in each component of the study. To show our appreciation for your time, we will give the study participant $300 if you complete all study related procedures and return all of the study equipment. You will only receive payment for visits that you complete, and you will be paid with ClinCard (debit card) after each visit. If you do not complete all study related procedures, you will receive a pro-rated reimbursement based on completed procedures as follows:
Consent visit (visit 1): $50
Baseline cognitive tests: $40
Baseline MRI scan: $30
Baseline PET Scan: $30
6-month visit: $50
12-month visit: $100
If you participate in the optional lumbar puncture (cerebrospinal fluid) sub-study,you will be compensated an additional $100 for each lumbar puncture (up to $200 for two).
Study Partner Compensation: You will be asked to identify a study partner, which can be a family member, neighbor or friend, who you have contact with at least 10 hours per week - phone or in-person. The study partner will be compensated up to $100 compensation for completed visits. The study partner will only receive payment for visits that he/she has completed, and he/she will be paid with ClinCard (debit card) after each visit. If the study partner can not attend all visits, they will receive a pro-rated reimbursement based on the visits they do not attend with the study participant as follows:
Consent visit (visit 1): $20
Baseline cognitive tests: $15
Baseline MRI scan: $15
Baseline PET Scan: $15
6-month visit: $15
12-month visit: $20