The natural history research on MS and the ability to use Magnetic Resonance Imaging (MRI) to monitor MS progression suggest that risk of relapse diminishes significantly as people age, especially those people who have not had relapses or MRI scan changes for at least 5 years. This study is designed to learn more about the safety of stopping MS medication in this group and compare their outcomes to other stable MS patients who continue taking their MS medications.
You are being invited to participate in a research study because you have multiple
sclerosis (MS) without recent disease activity, and have been on a stable MS
medication for the past 5 years.
This study will have 2 different groups of research subjects like you. One of
these groups will stay on their current MS medication, and one group will
discontinue their medication. To decide which group you will be in, we will use a
method of chance. This method is like flipping a coin or rolling dice. This is
In order to participate in this study, you must be OK with being randomized to
either group. (No matter which group you are randomized to, you will still be
able to leave the study at any time or your doctor may remove you from the
study as explained in the section·"can I be removed from this study?")
If you join the study, you will be randomized to one of the 2 groups as
described above. You will also have some extra assessments done at your
regular routine MS clinic appointment or at a separate research appointment
If you are randomized to the group to discontinue your medication, your doctor
will provide instructions to safely discontinue your MS medication.
This study will be conducted for two years. Up to 60 people from your area will
participate in the study. Up to 300 people around the country will be in the
Study Identifier: 826635
Contact the research team to learn more about this study.