Investigation of the Effect of Branched Chain Amino Acids on Fat-Induced Insulin Resistance in Healthy Adults.

Brief description of study

Elevations in plasma levels of branched chain amino acids (BCAAs, comprising leucine, valine, and isoleucine), a large component of protein, are strongly associated with insulin resistance and type 2 diabetes, but mechanisms for this relationship are unclear. This protocol will determine whether excess BCAAs worsen free fatty acid-induced insulin resistance. Following a small scale dose-confirmation study, insulin sensitivity in response to low-dose lipid infusion will be compared across simultaneous administrations of the 3 BCAAs, leucine alone, valine alone, or control to better understand the mechanistic contribution of each BCAA to the development of insulin resistance in humans.

Detailed description of study

1. Screening visit includes review of medical history, medications, and family history. ($60.00)

2. 4 Overnight visits which include blood draws, and study drug ($210.00)

Eligibility of study

You may be eligible for this study if you meet the following criteria:

Conditions:
Insulin Resistance,Healthy
Age: Between 18 Years - 39 Years
Gender: All

1. BMI 18.8</=27

2. Age 18 - 39

3. No smoking or use of tobacco products.

4. No more than 1 immediate family member with a diabetes diagnosis.

5. Participant cannot be diagnosed as pre-diabetic, or Type 1 or Type 2 diabetes.

Updated on 09 Mar 2024. Study ID: 831425

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