Mechanisms for Individual Differences in Hypertension in Obstructive Sleep Apnea
Brief description of study
The purpose of this study is to compare the response to PAP treatment of patients with Obstructive Sleep Apnea (OSA) who have normal blood pressure to those with treated (that is taking medication or on a special diet) high blood pressure.
Detailed description of study
OSA is a breathing disorder during sleep. It is caused by a blockage of the airway, usually when the soft tissue in the back of the throat collapses during sleep. OSA is believed to cause high blood pressure, heart attacks, stroke, and problems with control of blood sugar.
Positive Airway Pressure (PAP) is a treatment in which a mask is worn over the nose and/or mouth while you sleep. The mask is hooked up to a machine that delivers a flow of air to the mask. The positive flow of air helps keep the throat open so that breathing is not impaired.
We are enrolling patients with OSA who have either treated high blood pressure, uncontrolled high blood pressure, or normal blood pressure. You will be scheduled to have a series of tests at the start of the study and after 4 months of PAP treatment.
This study will take up to 24 weeks for you to finish. The entire study may last for 4 years. A total of 200 adults with OSA will be asked to take part at the University of Pennsylvania.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
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Conditions:
hypertension,sleep,OSA,sleep apnea,apnea,normal blood pressure,normal BP
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Age: Between 18 Years - 75 Years
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Gender: All
Updated on
03 Dec 2021.
Study ID: 823172
