SSRI Effects on Depression and Immunity in HIV/AIDS
The purpose of this study is to determine if a common anti-depressant called escitalopram, a type of Selective Serotonin Reuptake Inhibitor, (SSRI) can positively affect immunity - your body’s defense against infection - in depressed individuals living with HIV. We will study the direct effect of this SSRI on your immunity and we will also study if lessening of depressive symptoms can positively affect your immunity. This is a randomized, placebo-controlled study. “Randomization” means you will be put into a group by chance. It’s like flipping a coin. You have a 50% chance of being in the group that receives study medication and a 50% chance of being in the group that receives the placebo. “Placebo” is what we call the pill that looks exactly like the study medication pill, but it does not have the active medication in it. While the study medication is FDA approved for treating depression, because we are investigating its effects on your immunity, its use in this study is considered investigational.
- Study Identifier: 823405