Neural and Motor Functional Changes in HIV and Stroke Before and After Robot-Assisted Neurorehabilitation

Site Image

Study Overview

The purpose of this research study is twofold: to study the role HIV has on the brain’s function and more particularly, the relationship between HIV and stroke; and to study how the presence of HIV effects robot-assisted rehabilitation after stroke, and its association with clinical improvement.

Study Description

For this study, participants will be asked to visit the Rehabilitation Robotics Lab at the University of Pennsylvania, Penn Medicine Rittenhouse, Department of Physical Medicine and Rehabilitation, 1800 Lombard Street, 1st Floor, Philadelphia, PA  19146. 

Stroke participants will be asked to participate in 14 separate sessions.  This will include will include 2 clinical assessment sessions, 2 scanning sessions, and 12 therapy sessions over the course of 1.5 months.*  Prior to session 1 and after session 12, we will take images of the participant's brain in a fMRI machine.

HIV/AIDS participants that have not had a stroke will be asked to participate in 2-3 sessions.  This will include clinical evaluation assessment and 1-2 therapy sessions.* 

The custom robotic therapy devices include the Theradrive system, the BiAs system, the BiADLER system, and the ADLER system, administered in a randomized order.

A little bit about our robots:

TheraDrive - is a low-cost robotic system for post-stroke upper extremity
rehabilitation. The system uses off-the-shelf computer gaming wheels with force feedback to help reduce motor impairment and improve function in the arms of stroke survivors.

BiAS - Is a new low-cost, high-force haptic robot with a single degree of freedom has been developed and will provide information regarding the position and velocity of the wrist of each arm.

BiADLER - is a bi-armed therapy robot. Two manipulators, with 6 degrees of freedom each, are mounted on a table top. One arm is completely passive, while the other arm is active. 

ADLER- is a robot that will be used to measure motor skill learning across different populations. Varying the resistance and forces while performing certain tasks will allow this measurement.

*Participants may be videotaped or photographed in any one of the sessions for purposes of documenting our process.

Additional Information:

Participants will be compensated $15-25 for each session that they participate in via a loadable ClinCard.  

  • Study Identifier: 823511

Recruitment Status


Contact the research team to learn more about this study.

Fields marked with asterisk (*) are required

Please verify that you are not a bot.

By clicking "Contact Research Team", your contact information will be sent securely to the research staff associated with the study. You will also receive a copy of this email in your inbox, as well as other notifications to determine your participation status in the study.

Volunteer Sign up

Volunteer Sign-up

Participate in medical studies to develop new diagnostic and clinical treatments and improve current standards of care.

Sign Up Now!

If you need assistance finding a non-cancer study or if you have any questions, please email