A Phase 2 Randomized Blinded study of Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for the treatment of Chronic Aphasia

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Study Overview

The Laboratory for Cognition and Neural Stimulation (LCNS) is currently recruiting individuals who have suffered from stroke and are now experiencing aphasia, a loss or impairment of language abilities, for a clinical trial. The purpose of this study is to determine if Transcranial Magnetic Stimulation (TMS), a form of non-invasive brain stimulation, combined with speech therapy can be used as treatment technique to improve language. Researchers will also investigate the long-term effectiveness of TMS on language up to 6 months after TMS treatment.

Study Description

Patient's interested in participating will undergo a medical interview with a UPenn Neurologist to determine eligibility. Once enrolled patients will receive brain imaging (MRI), Transcranial Magnetic Stimulation (TMS), and speech therapy. TMS uses magnetic pulses to stimulate regions of the brain from outside the head, on the scalp. TMS can affect brain cells in specific locations of the brain. In this study, researchers will target language areas of the brain in an attempt to improve speech. This is a randomized trial, which means not all participants will receive real TMS. However, everyone in the study will have speech therapy. 

  • Study Identifier: 831532

Recruitment Status

Enrolling By Invitation

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