Measurement of Pulmonary Inflammation Using F-NOS Positron Emission Tomography (PET/CT) in E-cigarette Users

Measurement of Pulmonary Inflammation Using F-NOS Positron Emission Tomography (PET/CT) in E-cigarette Users

Brief description of study

This is a 2 visit study to occur over 1 – 2 months. This study examines and compares inflammation between e-cigarette/vape nicotine users, e-cigarette/vape cannabis users, cigarette smokers, dual users (e-cigarette/vape users and smokers of nicotine and cannabis), and non-smokers using a new radioactive tracer, FNOS.

**We are no longer enrolling NON-SMOKERS**
 
FNOS is an experimental radioactive tracer used to look for inflammation in different parts of the body. The tracer that we will be using has been shown to be safe for use on both humans and animals and allows us to effectively examine the level of inflammation in the lungs and throughout the body. The level of radiation you will be exposed to is very minimal and unlikely to have any effect on you.
 
Although some evidence suggests that e-cigarettes do not affect lung inflammation, very few studies have produced data to support that. The findings of this PET scan will help scientists better understand the effects of e-cigarette/vape smoking on the lungs compared to traditional smoking and the combination of the two. 

Detailed description of study

In this study, you will participate in only 2 visits (~2-3 hour visits): 
1) a combined consent and screening visit
2) one PET/CT lung scan to be scheduled over the course of approximately 6 weeks. 

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Nicotine Dependence,Lung Inflammation,healthy volunteer
  • Age: Between 18 Years - 45 Years
  • Gender: All

To participate in this study, you must 1)  smoke only cigarettes, use only e-cigarettes or vapes for either nicotine or cannabis, use both an e-cigarette and smoke combustible nicotine/cannabis, or be a non-smoker. 

**We are no longer enrolling NON-SMOKERS**

Updated on 01 Mar 2023. Study ID: 831205

Interested in the study

Select a study center that’s convenient for you, and get in touch with the study team.

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