Genome Research in African American Scleroderma
Brief Description Of Study
This research is being done to determine how variations in genes may explain the different risk to develop scleroderma seen in African American patients compare to other populations. The purpose of this study is to: A. Collect DNA and serum samples and clinical data from African American patients who are diagnosed with systemic sclerosis and followed in specialized clinical centers across the United States. B. To perform whole genome/exome sequencing in this patient population as well as in healthy African Americans and Western African control subjects. C. To create a serum bank to pursue future autoantibody testing and molecular studies based on initial findings of the genetic analysis D. To extract ancestry information from these data and perform a combined admixture and genome-wide association scan. There is only 1 study visit and a blood draw.