The Assessment of Prednisone In Remission Trial (TAPIR)
Brief description of study
The purpose of this study is to collect information about 2 different recommended treatments for granulomatosis with polyangiitis (GPA, Wegener’s). We want to find out whether patients with GPA do better if they stay on a maintenance dose of 5 mg of prednisone or come off of prednisone after GPA is well-controlled. There are 5 study visits and patients will be in the study for no longer than 18 months. To join this study, patients must have a GPA diagnosis and be taking prednisone.
Detailed description of study
Patients who are eligible may be enrolled when their daily dose of prednisone is between 5 mg and 20 mg. Everyone in this study will have their dose of prednisone decreased, unless they enter the study at 5 mg. Some patients will be randomized to decrease their prednisone to 0 mg, others to decrease or maintain their prednisone to 5 mg daily. Randomization means that the decision as to which option a person will receive is decided "by chance," not choice, like tossing a coin. Patients will complete surveys, have physical exams, and information from their medical record will be collected. This study is a project of the Vasculitis Clinical Research Consortium (VCRC), which is a network of investigators in major North American vasculitis centers. The VCRC is funded through the National Institutes of Health as a Rare Diseases Clinical Research Network with the purpose of promoting research in vasculitis.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
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Conditions:
Vasculitis,Granulomatosis with Polyangiit,GPA,Wegeners
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Age: Between 18 Years - 90 Years
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Gender: All
Updated on
08 Jul 2023.
Study ID: 818769