Sjogrens Screening Dry Eye Study

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Study Overview

The purpose of this study is to study and validate a new tool for screening dry eye patients for possible Sjogren's Syndrome (SS). This tool is composed of a combination of questionnaire responses and standard dry eye exam findings. Participating centers (Penn and Johns Hopkins University) will collect clinical data and specimens from dry eye patients who may or may not have SS. Specimens will include tears, saliva, whole blood, serum and labial minor salivary gland (lip) biopsy specimens. All individuals will participate in a standard evaluation protocol including an oral, ocular and physical examination, objective tests for dry eyes and dry mouth and, whenever necessary, a labial minor salivary gland biopsy. It is proposed that 40-50 patients per year at each site will be enrolled for the next 3-4 years at each site. 

Study Description

Study participation involves a 1.5-hour visit consisting of a dry eye examination, blood draw, salivary flow rate test, and answering questionnaires. Based on the results of this visit, certain participants may be invited to return for a lip biopsy.
 Qualified participants will receive $50 for completion of the initial visit and $150 for completion of the lip biopsy.

  • Study Identifier: 828400

Recruitment Status

Open

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