Acute and Long-term Effects of E-Cigarette Aerosol Inhalation on Biomarkers of Endothelial Function and Vascular Reactivity
The purpose of this study is 1) to examine the acute effects of nicotine free e-cigarette aerosol on vascular function in healthy, non-smokers and 2) to examine and compare vascular function in healthy smokers chronically exposed, at baseline and after 12 months, to nicotinized e-cigarette aerosol versus conventional cigarettes as compared to age, gender and body mass index-matched nonsmokers. Each participant, from both cohorts, will undergo 2 MRIs and 2 blood draws, per visit. All participants will be compensated for time taken to participate in the study. Key eligibility criteria include men and women, ages 18-45 with a BMI of 18.5-30. No contradictions with MRI.
Non-smokers: these participants will complete 1 study visit. The study visit will consist of 2 blood draws, 2 MRIs and 1 smoking encounter of a non-nicotine e-cigarette. These visits last around 3-3.5 hours. Smokers: these participants will complete 2 study visits. Of the smokers, there are 2 cohorts of interest: conventional and e-cigarette smokers. The baseline and 12 month visits will consist of 1 blood draw and one MRI. Each visit will last about 1.5 hours. Prior to enrollment, subjects will be asked to undergo a brief telephone screening to confirm eligibility. This will be done with the study coordinator.
- Study Identifier: 828195
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