Vasculitis Clinical Research Consortium Longitudinal Protocol for Aortitis: 5507
Brief Description Of Study
The purpose of this study is to 1) establish a longitudinal cohort of patients with different types of aortitis in order to clarify definitions/classification of different types of aortitis and to facilitate future clinical trials in this group of conditions, 2) characterize natural history of different types of aortitis, and 3) develop biomarkers that would predict evolution of different types of aortitis and predict outcomes of interest such as radiographic progression, clinical vascular complications and long-term damage. To serve this purpose, we will follow a large group of patients with different types of aortitis over several years. Blood, aortic tissue, and urine specimens will be sent to research laboratories that are looking to discover new proteins, genes, and other chemicals that could serve as new biomarkers.
Detailed Study Description
Clinical information and blood and urine specimens will be collected at yearly clinic visits. The types of information collected will include medical history details, medication use, physical examination findings, results of laboratory and diagnostic imaging tests. Whenever possible, copies of de-identified imaging studies will be collected and stored for future re-evaluation. Patients will be in the study for up to 10 years. This study is a project of the Vasculitis Clinical Research Consortium (VCRC), which is a consortium of investigators in major North American vasculitis centers. The VCRC is funded through the National Institutes of Health as a Rare Diseases Clinical Research Network with the purpose of promoting research in vasculitis.