T-Cell Response to Vaccination

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Study Overview

The purpose of this study is to see how your body forms a protective response after vaccination and how it deals with viral variants. We are studying the immune response to the COVID-19 vaccines. 

Study Description

The study consists of a screening visit followed by other study visits. From the time of screening, you will be in this study for around 9 months.
You may be eligible if you plan to receive the vaccine (initial or booster) but have not yet gotten it yet. 
The COVID-19 vaccination study includes: a screening visit (approx 1 hour) to check your eligibility. If you qualify, you will come in for the following study visits: Study Visit 1 - Pre-Donor Evaluation (30 min) and Leukopheresis (approx 2.5-4 hours), Visit 2 – vaccination at your place of choice. The study team will not be providing the vaccine. Study Visits 3 - 8 - Blood Draws (approx 30 mins), Study Visit 9 - Leukopheresis (approx 2.5-4 hours). 
There are additional optional procedures that you may choose to participate in. These include fine needle aspiration (FNA) of the lymph nodes under your armpit to see how protective antibodies are being generated. You may also choose to participate in periodic blood draws/leukopheresis to see how immune protection holds up over the long-term.

Additional Information:

Compensation is provided after the screening visit if eligible for the study.

  • Study Identifier: 820884

Recruitment Status


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Are you 18 years of age or older?
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If you need assistance finding a non-cancer study or if you have any questions, please email psom-ocr@pobox.upenn.edu