T-Cell Response to Vaccination

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Study Overview

The purpose of this study is to see how your body responds to a vaccine and how your body forms a protective response after vaccination. We are studying the immune response to the yellow fever vaccine and the COVID-19 vaccines. You may choose to participate in either arm of the study.

Study Description

The study consists of a screening visit followed by study visits. From the time of screening, you will be in this study for around 9 months.
The yellow fever arm of the study includes: Screening visit (approx 1 hour), Study visit 1 – Leukopheresis (approx 2.5 hours), Study Visit 2 - Vaccination (approx 45 mins), Study Visits 3-8 - Blood Draws (approx 30 mins), Study Visit 9 - Leukopheresis (approx 2.5 hours).
For the COVID-19 Vaccination arm, the study includes: Screening visit (approx 1 hour), Study visit 1 - Leukopheresis (approx 2.5 hours), Study Visit 2 – Vaccination/blood draw (approx 45 mins), Study Visits 3 - Blood Draw (approx 30 mins), Study Visit 4 - Re-Vaccination (approx 45 mins), Study Visits 5 - 9 - Blood Draws (approx 30 mins), Study Visit 10 - Leukopheresis (approx 2.5 hours). You may repeat the study visits if you are getting a COVID vaccine booster.
The study team will not be providing the vaccine but will reimburse you for the cost of the vaccine if you have to pay out of pocket.
There are additional optional procedures that you may choose to participate in. These include fine needle aspiration (FNA) of the lymph nodes under your armpit to see how protective antibodies are being generated. You may also choose to participate in periodic blood draws/leukopheresis to see how immune protection holds up over the long-term.

Additional Information:

The compensation for this study is broken down to $50 per blood draw and $200 per leukopheresis visit or FNA procedure. In total, you may be compensated up to $700 for a one-dose vaccine and up to $750 for a vaccine given in two doses. You will receive additional compensation for optional procedures. To participate in this study you must be at least 18 years old. 

  • Study Identifier: 820884

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If you need assistance finding a non-cancer study or if you have any questions, please email psom-ocr@pobox.upenn.edu