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T-Cell Response to Vaccination

Study Overview
The
purpose of this study is to see how your body responds to a vaccine and how
your body forms a protective response after vaccination. We are studying immune
response to the yellow fever vaccine and the COVID-19 vaccines. You may choose to participate in either arm of
the study.
Study Description
The
study consists of a screening visit followed by study visits. From the time of
screening, you will be in this study for between 8-12 months.
The
yellow fever arm of the study includes: Screening visit (approx 1 hour), Study
visit 1 – Leukopheresis (approx 2.5 hours), Study Visit 2 - Vaccination (approx
45 mins), Study Visits 3-8 - Blood Draws (approx 30 mins), Study Visit 9 -
Leukopheresis (approx 2.5 hours).
For the COVID-19 Vaccination
arm, the study includes: Screening visit (approx 1 hour), Study visit 1 -
Leukopheresis (approx 2.5 hours), Study Visit 2 – Vaccination/blood draw
(approx 45 mins), Study Visits 3 - Blood Draw (approx 30 mins), Study Visit 4 -
Re-Vaccination (approx 45 mins), Study Visits 5 - 9 - Blood Draws (approx
30 mins), Study Visit 10 - Leukopheresis (approx 2.5 hours).
The study team will not
be providing the vaccine but will reimburse you for the cost of the vaccine if
you have to pay out of pocket.
There are additional
optional procedures that you may choose to participate in. These include fine
needle aspiration (FNA) of the lymph nodes under your armpit after each vaccine
dose. You may also choose to participate in periodic blood draws/leukopheresis
to see how immune protection holds up over the long-term.
Additional Information:
The
compensation for this study is broken down to $50 per blood draw and $200 per
leukopheresis visit or FNA procedure. In total you may be compensated up to
$700 for the yellow fever arm of the study and up to $750 for the COVID-19 arm
of the study. You will receive additional compensation for optional procedures.
To participate in this study you must be at least 18 years old.
- Study Identifier: 820884