The Effect of Non-Cardiac Mechanisms on Exercise Capacity in Heart Failure Patients.

The Effect of Non-Cardiac Mechanisms on Exercise Capacity in Heart Failure Patients.

Brief description of study

This proposal will study why people stop exercising. Specifically, it will look at how the skeletal muscles and nerves interact with the heart and lungs during exercise to coordinate the body's response to exercise.The study will enroll individuals with heart failure with reduced ejection fraction (systolic heart failure).

Detailed description of study

On the study visit day, we will ask you to perform several tests related to exercise and muscle function, which will be discussed in detail below. Upon study visit arrival, we will obtain consent and answer any questions. We will draw baseline labs, perform brief physical exam, and record vital signs. We will then perform an echocardiogram followed by arterial tonometry, a non-invasive technique which measures the arterial pressure. Next, we will ask you to perform a maximal effort bike test followed by a DXA scan which measures bone mineral density, body fat, and lean mass. Lunch is provided. After lunch we will perform 4 series of handgrip testing, using a handgrip device. The first 2 handgrip series will be under room air and the last 2 you will be given 100% oxygen. The last test of the day is a cold pressor test. We will ask you to come in on a separate day to perform an MRI scan.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Chronic systolic (congestive)
  • Age: Between 18 Years - 100 Years
  • Gender: All
Updated on 14 Jul 2023. Study ID: 823756

Interested in the study

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